New DNA Vaccines Study Findings Recently Were Reported by Researchers at Institute of Infectious Disease (DNA vaccines for HFRS: Laboratory and clinical studies)
By a News Reporter-Staff News Editor at Life Science Weekly -- Researchers detail new data in Biotechnology. According to news reporting originating from Fort Detrick, Maryland, by NewsRx correspondents, research stated, "DNA vaccines can be constructed to produce specific immunogens while avoiding the risks associated with propagating infectious viruses. Plasmid DNA vaccines have well established manufacturing procedures and are safe in that they are replication defective, cannot revert to virulence and cannot be transmitted from person-to-person or into the environment."
Our news editors obtained a quote from the research from the Institute of Infectious Disease, "In addition, DNA vaccines can be combined to form multivalent formulations and can be delivered by a variety of methods. Because of these numerous advantages, we have developed DNA vaccines expressing the envelope glycoprotein genes of hantaviruses causing hemorrhagic fever with renal syndrome (HFRS). We have demonstrated that these DNA vaccines elicit neutralizing antibodies in multiple laboratory animal species when delivered to skin or muscle tissues. Moreover, these vaccines delivered as active vaccines or passive vaccines (e.g., transfer of sera from vaccinated rabbits or nonhuman primates), protected hamsters from infection with HFRS-causing hantaviruses. Early clinical studies of HFRS vaccines expressing Hantaan virus or Puumala virus genes have been completed and show promise for further development."
According to the news editors, the research concluded: "Despite these advantages, issues relating to inconsistent immunogenicity and immune interference remain to be addressed. ."
For more information on this research see: DNA vaccines for HFRS: Laboratory and clinical studies. Virus Research, 2014;187():91-96. Virus Research can be contacted at: Elsevier Science Bv, PO Box 211, 1000 Ae Amsterdam, Netherlands. (Elsevier - www.elsevier.com; Virus Research - www.elsevier.com/wps/product/cws_home/506054)
The news editors report that additional information may be obtained by contacting C.S. Schmaljohn, US Army, Medical Res Inst Infect Dis, Fort Detrick, MD 21702, United States. Additional authors for this research include K.W. Spik and J.W. Hooper (see also Biotechnology).
Keywords for this news article include: Biotechnology, Maryland, Viral DNA, Hantavirus, RNA Viruses, Fort Detrick, Bunyaviridae, DNA Research, DNA Vaccines, United States, Synthetic Vaccines, North and Central America
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