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New DNA Research Study Results Reported from Hong Kong University of Science and Technology (Triggering Hairpin-Free Chain-Branching Growth of...

August 19, 2014



New DNA Research Study Results Reported from Hong Kong University of Science and Technology (Triggering Hairpin-Free Chain-Branching Growth of Fluorescent DNA Dendrimers for Nonlinear Hybridization Chain Reaction)

By a News Reporter-Staff News Editor at Life Science Weekly -- New research on DNA Research is the subject of a report. According to news reporting originating from Hong Kong, People's Republic of China, by NewsRx correspondents, research stated, "We present a nonlinear hybridization chain reaction (HCR) system in which a trigger DNA initiates self-sustained assembly of quenched double-stranded substrates into fluorescent dendritic nanostructures. During the process, an increasing number of originally sequestered trigger sequences labeled with fluorescent reporters are freed up from quenched substrates, leading to chain-branching growth of the assembled DNA dendrimers and an exponential increase in the fluorescence intensity."

Our news editors obtained a quote from the research from the Hong Kong University of Science and Technology, "The triggered assembly behavior was examined by PAGE analysis, and the morphologies of the grown dendrimers were verified by AFM imaging. The exponential kinetics of the fluorescence accumulation was also confirmed by time-dependent fluorescence spectroscopy."

According to the news editors, the research concluded: "This method adopts a simple sequence design strategy, the concept of which could be adapted to program assembly systems with higher-order growth kinetics."

For more information on this research see: Triggering Hairpin-Free Chain-Branching Growth of Fluorescent DNA Dendrimers for Nonlinear Hybridization Chain Reaction. Journal of the American Chemical Society, 2014;136(28):9810-9813. Journal of the American Chemical Society can be contacted at: Amer Chemical Soc, 1155 16TH St, NW, Washington, DC 20036, USA. (American Chemical Society - www.acs.org; Journal of the American Chemical Society - www.pubs.acs.org/journal/jacsat)

The news editors report that additional information may be obtained by contacting F. Xuan, Hong Kong University of Science & Technology, Div Biomed Engn, Kowloon, Hong Kong, People's Republic of China (see also DNA Research).

Keywords for this news article include: Asia, Hong Kong, DNA Research, People's Republic of China

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Life Science Weekly


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