New Chemotherapy Data Have Been Reported by Investigators at Fourth Military Medical University (PEG-detachable lipid-polymer hybrid nanoparticle for delivery of chemotherapy drugs to cancer cells)
By a News Reporter-Staff News Editor at Biotech Week -- Current study results on Drugs and Therapies have been published. According to news originating from Xi'an, People's Republic of China, by NewsRx correspondents, research stated, "The experiment aimed to increase the drug-delivery efficiency of poly-lactic-co-glycolic acid (PLGA) nanoparticles. Lipid-polymer hybrid nanoparticles (LPNs-1) were prepared using PLGA as a hydrophobic core and FA-PEG-hyd-DSPE as an amphiphilic shell."
Our news journalists obtained a quote from the research from Fourth Military Medical University, "Uniform and spherical nanoparticles with an average size of 185 nm were obtained using the emulsification solvent evaporation method. The results indicated that LPNs-1 showed higher drug loading compared with naked PLGA nanoparticles (NNPs). Drug release from LPNs-1 was faster in an acidic environment than in a neutral environment. LPNs-1 showed higher cytotoxicity on KB cells, A549 cells, MDA-MB-231 cells, and MDA-MB-231/ADR cells compared with free doxorubicin (DOX) and NNPs. The results also showed that, compared with free DOX and NNPs, LPNs-1 delivered more DOX to the nuclear of KB cells and MDA-MB-231/ADR cells. LPNs-1 induced apoptosis in KB cells and MDA-MB-231/ADR cells in a dose-dependent manner. The above data indicated that DOX-loaded LPNs-1 could kill not only normal tumor cells but also drug-resistant tumor cells."
According to the news editors, the research concluded: "These results indicated that modification of PLGA nanoparticles with FA-PEG-hyd-DSPE could considerably increase the drug-delivery efficiency and LPNs-1 had potential in the delivery of chemotherapeutic agents in the treatment of cancer."
For more information on this research see: PEG-detachable lipid-polymer hybrid nanoparticle for delivery of chemotherapy drugs to cancer cells. Anti-Cancer Drugs, 2014;25(7):751-766. Anti-Cancer Drugs can be contacted at: Lippincott Williams & Wilkins, 530 Walnut St, Philadelphia, PA 19106-3621, USA. (Lippincott Williams and Wilkins - www.lww.com; Anti-Cancer Drugs - journals.lww.com/anti-cancerdrugs/pages/default.aspx)
The news correspondents report that additional information may be obtained from J.B. Du, Fourth Military Medical University, Sch Pharm, Dept. of Pharmaceut, Xian 710032, Shaanxi Provinc, People's Republic of China. Additional authors for this research include Y.F. Song, W.L. Ye, Y. Cheng, H. Cui, D.Z. Liu, M. Liu, B.L. Zhang and S.Y. Zhou (see also Drugs and Therapies).
Keywords for this news article include: Asia, Xi'an, Cancer, KB Cells, Oncology, Cell Line, Hela Cells, Chemotherapy, Nanoparticle, Nanotechnology, Drugs and Therapies, Emerging Technologies, People's Republic of China
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