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New Cardiovascular Research Study Results from George W. Woodruff School of Mechanical Engineering Described (Endothelial retention and phenotype on...

August 22, 2014

New Cardiovascular Research Study Results from George W. Woodruff School of Mechanical Engineering Described (Endothelial retention and phenotype on carbonized cardiovascular implant surfaces)

By a News Reporter-Staff News Editor at Drug Week -- Fresh data on Cardiovascular Research are presented in a new report. According to news reporting out of Atlanta, Georgia, by NewsRx editors, research stated, "Heart valve disease is an increasing clinical burden for which there is no effective treatment outside of prosthetic replacement. Over the last 20 years, clinicians have increasingly preferred the use of biological prosthetics to mechanical valves despite their superior durability because of the lifelong anticoagulation therapy that is required."

Our news journalists obtained a quote from the research from the George W. Woodruff School of Mechanical Engineering, "Mechanical valve surface engineering has largely focused on being as non-thrombogenic as possible, but despite decades of iteration has had insufficient impact on the anticoagulation burden. In this study, we systematically evaluate the potential for endothelialization of the pyrolytic carbon surface used in mechanical valves. We compared adsorbed adhesion ligand type (collagen I, fibronectin, laminin, and purified adhesion domain fragments GFOGER and FN7-10) and concentration on endothelial adhesion rates and adhesion strength on Medtronic-Hall prosthetic valve surfaces. Regardless of ligand type or concentration, endothelial adhesion strengthening was insufficient for their intended ultra-high shear stress environment. We then hypothesized that microfabricated trenches would reduce shear stress to tolerable levels while maintaining endothelial access to the flow stream, thereby promoting a confluent and anticoagulant endothelial monolayer. Computational fluid dynamics simulations predicted an empirical relationship of channel width, depth, and spacing that would maintain interior surface shear stress within tolerable levels. Endothelial cells seeded to confluence in these channels retained a confluent monolayer when exposed to 600 dyn/cm(2) shear stress for 48 h regardless of applied adhesive ligand. Furthermore, sheared EC expressed a mature anti-coagulant profile, including endothelial nitric oxide synthase (eNOS), VE-cadherin, and significantly downregulated plasminogen activator inhibitor-1 (PAI-1). As a final test, channeled pyrolytic carbon surfaces with confluent EC reduced human platelet adhesion 1000-fold over pyrolytic carbon alone."

According to the news editors, the research concluded: "These results advance a promising biohybrid approach to enable active moderation of local coagulative response in mechanical heart valves, which could significantly extend the utility of this important treatment for heart valve disease."

For more information on this research see: Endothelial retention and phenotype on carbonized cardiovascular implant surfaces. Biomaterials, 2014;35(27):7714-7723. Biomaterials can be contacted at: Elsevier Sci Ltd, The Boulevard, Langford Lane, Kidlington, Oxford OX5 1GB, Oxon, England. (Elsevier -; Biomaterials -

Our news journalists report that additional information may be obtained by contacting C.M. Frendl, Georgia Inst Technol, George W Woodruff Sch Mech Engn, Atlanta, GA 30332, United States. Additional authors for this research include S.M. Tucker, N.A. Khan, M.B. Esch, S. Kanduru, T.M. Cao, A.J. Garcia, M.R. King and J.T. Butcher (see also Cardiovascular Research).

Keywords for this news article include: Atlanta, Georgia, Cardiology, United States, Cardiovascular Research, North and Central America

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Source: Drug Week

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