New Cancer Therapy Study Findings Have Been Reported by Researchers at University of Chicago (Self-assembled nanoscale coordination polymers with trigger release properties for effective anticancer therapy)
By a News Reporter-Staff News Editor at Biotech Week -- New research on Oncology is the subject of a report. According to news reporting from Chicago, Illinois, by NewsRx journalists, research stated, "Nanoscale coordination polymers (NCPs) are self-assembled from metal ions and organic bridging ligands, and can overcome many drawbacks of existing drug delivery systems by virtue of tunable compositions, sizes and shapes, high drug loadings, ease of surface modification and intrinsic biodegradability. Here we report the self-assembly of zinc bisphosphonate NCPs that carry 48 ± 3 wt% cisplatin prodrug and 45 ± 5 wt% oxaliplatin prodrug."
The news correspondents obtained a quote from the research from the University of Chicago, "In vivo pharmacokinetic studies in mice show minimal uptake of pegylated NCPs by the mononuclear phagocyte system and excellent blood circulation half-lives of 16.4 ± 2.9 and 12.0 ± 3.9 h for the NCPs carrying cisplatin and oxaliplatin, respectively. In all tumor xenograft models evaluated, including CT26 colon cancer, H460 lung cancer and AsPC-1 pancreatic cancer, pegylated NCPs show superior potency and efficacy compared with free drugs."
According to the news reporters, the research concluded: "As the first example of using NCPs as nanotherapeutics with enhanced antitumour activities, this study establishes NCPs as a promising drug delivery platform for cancer therapy."
For more information on this research see: Self-assembled nanoscale coordination polymers with trigger release properties for effective anticancer therapy. Nature Communications, 2014;5():4182. (Nature Publishing Group - www.nature.com/; Nature Communications - www.nature.com/ncomms/)
Our news journalists report that additional information may be obtained by contacting D. Liu, Dept. of Chemistry, University of Chicago, 929 East 57th Street, Chicago, Illinois 60637, United States. Additional authors for this research include C. Poon, K. Lu, C. He and W. Lin (see also Oncology).
Keywords for this news article include: Cancer, Chicago, Therapy, Illinois, Oncology, United States, North and Central America.
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