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New Biomedicine and Biomedical Engineering Findings from Emory University Reported (Molecular Sequelae of Topographically Guided Peripheral Nerve...

August 20, 2014

New Biomedicine and Biomedical Engineering Findings from Emory University Reported (Molecular Sequelae of Topographically Guided Peripheral Nerve Repair)

By a News Reporter-Staff News Editor at Biotech Week -- Research findings on Biotechnology are discussed in a new report. According to news reporting originating from Atlanta, Georgia, by NewsRx correspondents, research stated, "Peripheral nerve injuries cause severe disability with decreased nerve function often followed by neuropathic pain that impacts the quality of life. Even though use of autografts is the current gold standard, nerve conduits fabricated from electrospun nanofibers have shown promise to successfully bridge critical length nerve gaps."

Our news editors obtained a quote from the research from Emory University, "However, in depth analysis of the role of topographical cues in the context of spatio-temporal progression of the regenerative sequence has not been elucidated. Here, we explored the influence of topographical cues (aligned, random, and smooth films) on the regenerative sequence and potential to successfully support nerve regeneration in critical size gaps. A number of key findings emerged at the cellular, cytokine and molecular levels from the study. Higher quantities of IL-1 alpha and TNF-alpha were detected in aligned fiber based scaffolds. Differential gene expression of BDNF, NGFR, ErbB2, and ErbB3 were observed suggesting a role for these genes in influencing Schwann cell migration, myelination, etc. that impact the regeneration in various topographies. Fibrin matrix stabilization and arrest of nerve-innervated muscle atrophy was also evident."

According to the news editors, the research concluded: "Taken together, our data shed light on the cascade of events that favor regeneration in aligned topography and should stimulate research to further refine the strategy of nerve regeneration using topographical cues."

For more information on this research see: Molecular Sequelae of Topographically Guided Peripheral Nerve Repair. Annals of Biomedical Engineering, 2014;42(7):1436-1455. Annals of Biomedical Engineering can be contacted at: Springer, 233 Spring St, New York, NY 10013, USA. (Springer -; Annals of Biomedical Engineering -

The news editors report that additional information may be obtained by contacting V. Mukhatyar, Emory University, Neurol Biomat & Canc Therapeut Lab, Wallace H Coulter Dept. of Biomed Engn, Georgia Inst TechnolSch Med, Atlanta, GA 30332, United States. Additional authors for this research include B. Pai, I. Clements, A. Srinivasan, R. Huber, A. Mehta, S. Mukhopadaya, S. Rudra, G. Patel, L. Karumbaiah and R. Bellamkonda (see also Biotechnology).

Keywords for this news article include: Biotechnology, Atlanta, Georgia, United States, North and Central America

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Source: Biotech Week

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