Findings from Tohoku University Yields New Data on Immunologic Receptors (Pulmonary administration of integrin-nanoparticles regenerates collapsed alveoli)
By a News Reporter-Staff News Editor at Drug Week -- Current study results on Membrane Proteins have been published. According to news reporting from Miyagi, Japan, by NewsRx journalists, research stated, "Chronic obstructive pulmonary disease (COPD) is an intractable pulmonary disease, causes widespread and irreversible alveoli collapse. In search of a treatment target molecule, which is able to regenerate collapsed alveoli, we sought to identify a factor that induces differentiation in human alveolar epithelial stem cells using all-trans retinoic acid (ATRA), whose alveolar repair capacity has been reported in animal experiments."
The news correspondents obtained a quote from the research from Tohoku University, "When human alveolar epithelial stem cells were exposed to ATRA at a concentration of 10 mu M for over seven days, approximately 20% of the cells differentiated into each of the type-I and type-II alveolar epithelial cells that constitute the alveoli. In a microarray analysis, integrin-alpha 1 and integrin-beta 3 showed the largest variation in the ATRA-treated group compared with the controls. Furthermore, the effect of the induction of differentiation in human alveolar epithelial stem cells using ATRA was suppressed by approximately one-fourth by siRNA treatments with integrin alpha 1 and integrin beta 3. These results suggested that integrin alpha 1 and beta 3 are factors responsible for the induction of differentiation in human alveolar epithelial stem cells. We accordingly investigated whether integrin nanoparticles also had a regenerative effect in vivo. Elastase-induced COPD model mouse was produced, and the alveolar repair effect of pulmonary administration using nanoparticles of integrin protein was evaluated by X-ray CT scanning. Improvement in the CT value in comparison with an untreated group indicated that there was an alveolar repair effect. In this study, it was shown that the differentiation-inducing effect on human alveolar epithelial stem cells by ATRA was induced by increased expression of integrin, and that the induced integrin enhanced phosphorylation signaling of AKT, resulting in inducing differentiations. Furthermore, the study demonstrated that lung administration of nanoparticles with increased solubility and stability of integrin repaired the alveolus of an Elastase-induced COPD model mouse."
According to the news reporters, the research concluded: "Those results show that those integrin nanoparticles are effective as novel COPD treatment target compounds."
For more information on this research see: Pulmonary administration of integrin-nanoparticles regenerates collapsed alveoli. Journal of Controlled Release, 2014;187():167-174. Journal of Controlled Release can be contacted at: Elsevier Science Bv, PO Box 211, 1000 Ae Amsterdam, Netherlands. (Elsevier - www.elsevier.com; Journal of Controlled Release - www.elsevier.com/wps/product/cws_home/502690)
Our news journalists report that additional information may be obtained by contacting M. Horiguchi, Tohoku University, Grad Sch Med, Dept. of Adv Prevent Med Infect Dis, Sendai, Miyagi 9808575, Japan. Additional authors for this research include H. Kojima, H. Sakai, H. Kubo and C. Yamashita (see also Membrane Proteins).
Keywords for this news article include: Asia, Japan, Miyagi, Elastase, Integrins, Nanoparticle, Nanotechnology, Membrane Proteins, Emerging Technologies, Enzymes and Coenzymes, Immunologic Receptors
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