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Findings from Massachusetts General Hospital Broaden Understanding of Genetics and Dystonia (Microfluidic platform to evaluate migration of cells...

August 22, 2014



Findings from Massachusetts General Hospital Broaden Understanding of Genetics and Dystonia (Microfluidic platform to evaluate migration of cells from patients with DYT1 dystonia)

By a News Reporter-Staff News Editor at Genomics & Genetics Weekly -- Data detailed on Nervous System Diseases and Conditions have been presented. According to news reporting out of Charlestown, Massachusetts, by NewsRx editors, research stated, "Microfluidic platforms for quantitative evaluation of cell biologic processes allow low cost and time efficient research studies of biological and pathological events, such as monitoring cell migration by real-time imaging. In healthy and disease states, cell migration is crucial in development and wound healing, as well as to maintain the body's homeostasis."

Our news journalists obtained a quote from the research from Massachusetts General Hospital, "New method: The microfluidic chambers allow precise measurements to investigate whether fibroblasts carrying a mutation in the TOR1A gene, underlying the hereditary neurologic disease - DYT1 dystonia, have decreased migration properties when compared to control cells. We observed that fibroblasts from DYT1 patients showed abnormalities in basic features of cell migration, such as reduced velocity and persistence of movement. Comparison with existing method: The microfluidic method enabled us to demonstrate reduced polarization of the nucleus and abnormal orientation of nuclei and Golgi inside the moving DYT1 patient cells compared to control cells, as well as vectorial movement of single cells."

According to the news editors, the research concluded: "We report here different assays useful in determining various parameters of cell migration in DYT1 patient cells as a consequence of the TOR1A gene mutation, including a microfluidic platform, which provides a means to evaluate real-time vectorial movement with single cell resolution in a three-dimensional environment.."

For more information on this research see: Microfluidic platform to evaluate migration of cells from patients with DYT1 dystonia. Journal of Neuroscience Methods, 2014;232():181-188. Journal of Neuroscience Methods can be contacted at: Elsevier Science Bv, PO Box 211, 1000 Ae Amsterdam, Netherlands. (Elsevier - www.elsevier.com; Journal of Neuroscience Methods - www.elsevier.com/wps/product/cws_home/506079)

Our news journalists report that additional information may be obtained by contacting F.C. Nery, Massachusetts General Hospital, BioMEMS Resource Center, Dept. of Surg, Charlestown, MA 02129, United States. Additional authors for this research include C.C. da Hora, N.A. Atai, E.Y. Kim, J. Hettich, T.R. Mempel, X.O. Breakefield and D. Irimia (see also Nervous System Diseases and Conditions).

Keywords for this news article include: Dystonia, Genetics, Charlestown, Dyskinesias, Massachusetts, United States, North and Central America, Neurologic Manifestations, Nervous System Diseases and Conditions

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Genomics & Genetics Weekly


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