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Findings from Johns Hopkins University Provide New Insights into Extracellular Matrix Proteins (Vitrified collagen-based conjunctival equivalent for...

August 19, 2014

Findings from Johns Hopkins University Provide New Insights into Extracellular Matrix Proteins (Vitrified collagen-based conjunctival equivalent for ocular surface reconstruction)

By a News Reporter-Staff News Editor at Life Science Weekly -- New research on Proteins is the subject of a report. According to news reporting originating from Baltimore, Maryland, by NewsRx correspondents, research stated, "The main functions of the conjunctiva, an essential part of the ocular surface, are to maintain the equilibrium of the tear film and to protect the eye. Upon injuries, the prerequisite to successful ocular surface repair is conjunctival reconstruction."

Our news editors obtained a quote from the research from Johns Hopkins University, "Tissue engineering techniques, including transplantation of autografts, amniotic membranes and numerous synthetic/natural materials, have been developed. However, none of these strategies is completely satisfactory due to lack of goblet cell repopulation, poor mechanical properties or non-standardized preparation procedure. Here, we cultured conjunctival epithelial cells on vitrified collagen membranes and developed a tissue equivalent for repairing damaged conjunctiva. Optimized vitrified collagen has superior mechanical and optical properties to previous biomaterials for ocular surface application, and its unique fibrillar structure significantly benefited conjunctival epithelial cell growth and the phenotypic development in vitro. In a rabbit model, vitrified collagen greatly promoted conjunctival regeneration with rapid re-epithelization, sufficient repopulation of goblet cells and minimized fibrosis and wound contracture, proved by gene expression analyses and histological staining."

According to the news editors, the research concluded: "We have demonstrated the potential suitability of utilizing vitrified collagen-based tissue equivalent in ocular surface reconstruction."

For more information on this research see: Vitrified collagen-based conjunctival equivalent for ocular surface reconstruction. Biomaterials, 2014;35(26):7398-7406. Biomaterials can be contacted at: Elsevier Sci Ltd, The Boulevard, Langford Lane, Kidlington, Oxford OX5 1GB, Oxon, England. (Elsevier -; Biomaterials -

The news editors report that additional information may be obtained by contacting H.F. Zhou, Johns Hopkins Sch Med, Wilmer Eye Inst, Oculoplast Div, Ocular & Orbital Trauma Center, Baltimore, MD 21231, United States. Additional authors for this research include Q.Z. Lu, Q.Y. Guo, J. Chae, X.Q. Fan, J.H. Elisseeff and M.P. Grant (see also Proteins).

Keywords for this news article include: Maryland, Collagen, Baltimore, United States, North and Central America, Extracellular Matrix Proteins

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Source: Life Science Weekly

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