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Findings from J.M. Pitt and Co-Authors in the Area of Transport Vesicles Reported (Dendritic Cell-Derived Exosomes as Immunotherapies in the Fight...

August 18, 2014



Findings from J.M. Pitt and Co-Authors in the Area of Transport Vesicles Reported (Dendritic Cell-Derived Exosomes as Immunotherapies in the Fight against Cancer)

By a News Reporter-Staff News Editor at Cancer Vaccine Week -- Data detailed on Transport Vesicles have been presented. According to news originating from Villejuif, France, by NewsRx correspondents, research stated, "Exosomes are nanometric membrane vesicles of late endosomal origin released by most, if not all, cell types as a means of sophisticated intercellular communication. A multitude of studies showed how exosomes can mediate and regulate immune responses against tumors."

Our news journalists obtained a quote from the research, "Dendritic cell-derived exosomes (Dex) have received much attention as immunotherapeutic anticancer agents since the discovery that they harbor functional MHC-peptide complexes, in addition to various other immune-stimulating components, that together facilitate immune cell-dependent tumor rejection. The therapeutic potential of Dex has been substantiated with their development and clinical testing in the treatment of cancer."

According to the news editors, the research concluded: "This review focuses on mechanisms by which Dex interact with and influence immune cells and describes how they can be engineered to promote their immunogenic capacity as novel and dynamic anticancer agents."

For more information on this research see: Dendritic Cell-Derived Exosomes as Immunotherapies in the Fight against Cancer. Journal of Immunology, 2014;193(4):1006-1011. Journal of Immunology can be contacted at: Amer Assoc Immunologists, 9650 Rockville Pike, Bethesda, MD 20814, USA. (The American Association of Immunologists - www.aai.org; Journal of Immunology - www.jimmunol.org)

The news correspondents report that additional information may be obtained from J.M. Pitt, Center Clin Invest Biotherapies Canc 507, F-98405 Villejuif, France. Additional authors for this research include M. Charrier, S. Viaud, F. Andre, B. Besse, N. Chaput and L. Zitvogel (see also Transport Vesicles).

Keywords for this news article include: Antigen-Presenting Cells, France, Europe, Cancer, Exosomes, Oncology, Villejuif, Immunology, Organelles, Dendritic Cells, Transport Vesicles, Cytoplasmic Structures, Mononuclear Phagocyte System

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Cancer Vaccine Week


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