The patent describes and claims a targeted drug delivery method that combines bacterial minicells and a "bispecific ligand" in a composition lacking undesirable contamination from parent bacterial cells and so-called membrane blebs. The patented method draws on important discoveries by EnGeneIC inventors, including their finding that a range of different cancer cells, although non-phagocytic, nevertheless internalize drug-packaged minicells when they are targeted to the cells by a suitable bispecific ligand.
The inventors also discovered that any one of a variety of structurally dissimilar chemotherapeutic drugs can be packaged effectively into intact minicells. The EnGeneIC methodology therefore opens the way to exploiting drug candidates that have been deemed too toxic for human application.
About EDV™ Nanocell Technology
EnGeneIC's bacterially-derived EDV™ nanocells are a powerful nanoparticle drug delivery system designed to directly target and effectively kill tumor cells with minimal toxicity, while at the same time stimulate the immune system's natural anti-tumor response.
Intravenously injected EDV™ nanocells exit the leaky vascular system only within tumors and attach to cancer cells via a specially designed, targeted bi-specific antibody. Once attached, the nanocell is able to enter the tumor cell and deliver a drug payload of up to one million drug molecules per nanocell. In parallel, the bacterial cell wall of the nanocells stimulates key components of the immune system, which are then activated to seek out and destroy cancer cells.
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