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Data from Wuhan University Provide New Insights into Epithelial Cells (Exploring Sialic Acid Receptors-Related Infection Behavior of Avian Influenza...

August 19, 2014



Data from Wuhan University Provide New Insights into Epithelial Cells (Exploring Sialic Acid Receptors-Related Infection Behavior of Avian Influenza Virus in Human Bronchial Epithelial Cells by Single-Particle Tracking)

By a News Reporter-Staff News Editor at Life Science Weekly -- Fresh data on Epithelial Cells are presented in a new report. According to news reporting originating from Wuhan, People's Republic of China, by NewsRx correspondents, research stated, "Human respiratory tract epithelial cells are the portals of human infection with influenza viruses. However, the infection pathway of individual avian influenza viruses in human respiratory cells remains poorly reported so far."

Our news editors obtained a quote from the research from Wuhan University, "The single-particle tracking technique (SPT) is a powerful tool for studying the transport mechanism of biomolecules in live cells. In this work, we use quantum dots to label avian influenza H9N2 virus and elaborate on the infection mechanism of the virus in human bronchial epithelial (HBE) cells using a three-dimensional SPT technique. We have found that the H9N2 virus can infect HBE cells directly and the virus infection follows an actin filament-and microtubule-dependent process with a three-stage pattern. The transport behaviors show a high degree of consistency between the sialic acid receptors and the influenza virus. Real-time SPT provides dynamic evidence of the sialic acid receptors-related infection behavior of the avian influenza virus in live cells."

According to the news editors, the research concluded: "The study of the influence of sialic acid receptors on virus infection may contribute to a better understanding of the cross-species transmission of the avian influenza virus."

For more information on this research see: Exploring Sialic Acid Receptors-Related Infection Behavior of Avian Influenza Virus in Human Bronchial Epithelial Cells by Single-Particle Tracking. Small, 2014;10(13):2712-2720. Small can be contacted at: Wiley-V C H Verlag Gmbh, Boschstrasse 12, D-69469 Weinheim, Germany. (Wiley-Blackwell - www.wiley.com/; Small - onlinelibrary.wiley.com/journal/10.1002/(ISSN)1613-6829)

The news editors report that additional information may be obtained by contacting Z.G. Wang, Wuhan University, Wuhan Inst Biotechnol, Wuhan 430072, People's Republic of China. Additional authors for this research include S.L. Liu, Z.L. Zhang, Z.Q. Tian, H.W. Tang and D.W. Pang (see also Epithelial Cells).

Keywords for this news article include: Asia, Wuhan, Sialic Acids, Hydroxy Acids, Carboxylic Acids, Epithelial Cells, Neuraminic Acids, Organic Chemicals, People's Republic of China

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Life Science Weekly


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