Titled “Bio-Inspired Cryo-Ink Preserves Red Blood Cell Phenotype and Function During Nanoliter Vitrification”, the study describes the use of a bio-printer which generates nanoliter droplets containing red blood cells (RBCs). The RBCs can then be rapidly vitrified using a bio-inspired cryoprotectant. The cryoprotectant in question is glycerol- and DMSO-free and based on ectoine, a naturally occurring organic compound, while the cryo-printer is composed of an ejector-based system which produces nanoliter-volume droplets.
“As we are going into a new phase of advanced bio/nano-manufacturing technologies, where we create 3-D tissue like constructs mimicking native tissues for drug testing, cellular therapies for tissue engineering and regenerative medicine; there is a significant need to develop tools and innovative materials for biopreserving these living constructs. We need to focus on preserving function with fundamentally different approaches to biopreservation. The technology results in improved RBC morphology, mechanics, and function compared to other cryopreservation approaches, and minimizes RBC cryo-injury associated with the freezing process,” said Dr.
“We are extremely pleased to have contributed to this study which has enormous implications for blood banking,” said Dr.
Other authors of the study include
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