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1st Mideast productionof cefazolin active ingredient

August 11, 2014

1st Mideast productionof cefazolin active ingredient

Science & Technology Desk

Researchers at Dana Pharmaceutical Company in Tabriz, northwestern Iran, have produced the active ingredient of cefazolin sodium-sterile water IV for the first time in the Middle East.  

Cefazolin is an antibiotic used to treat a wide variety of bacterial infections. It may also be used before and during certain surgeries to help prevent infection. This medication works by stopping the growth of bacteria.

Ahmad Kharezi, managing director of the company, said manufacturing lines of active ingredients of clavulanate potassium, amoxicillin, soft gels and glass vials were also recently launched by the company.

He noted that 95 percent of Iranian needs for medicines are met domestically.

The pharmaceutical company's products meet the international Good Manufacturing Practices (GMP) standards.

GMP are practices required to conform to guidelines recommended by agencies that control authorization and licensing for manufacture and sale of food, medicines and pharmaceutical products.





New microscope allows look inside cells

The University of California, San Diego's Nanofabrication Cleanroom Facility (Nano3) is the first institution to obtain a novel FEI Scios dual-beam microscope, with an adaptation for use at cryogenic temperatures.

The new microscope will enable research among a highly diverse user base, ranging from materials science to structural and molecular biology, Topix wrote.

"The instrument provides state-of-the-art capabilities for cross-sectioning, preparation of sections for Transmission Electron Microscopy and more," Nano3 Technical Director Bernd Fruhberger adds.

"But what truly differentiates it is the novel cryo-capability, which will make it possible for cell biologists to see the structures of biological cells in higher resolution to better understand how cells function at a molecular level. This could possibly pave the way for new treatments and drug discovery."

Elizabeth Villa, a new assistant professor in the Department of Chemistry & Biochemistry at UC San Diego, adapted a focused-ion-beam microscope for biological applications during her postdoctoral studies.

"Only I'm using electron microscopy, which gives us higher-resolution images. The idea behind our method is to bring together people who do structural biology with people who do cell biology by using a new tool that will allow us to see the structures of the cells, at high resolution, and better understand what molecules are doing," explains Villa.

Electron microscopy has its downside. Traditionally, to be visible, cells must be prepared beforehand by drying and staining them with what Villa equates to a "thick layer of paint."

However, most cells are too thick to be studied this way, and that's what makes the Scios tool a game changer: It allows Villa to bypass the stain and nanomachine the cells to reduce them to the thickness required for electron microscopy—around a few tenths of a micron—without creating any sample distortions and while maintaining cryogenic temperatures (generally the temperature of liquid nitrogen).

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Source: Iran Daily

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