News Column

University of Turku Describes Findings in Proteomics (Identification of protein interactions involved in cellular signaling)

July 15, 2014



By a News Reporter-Staff News Editor at Life Science Weekly -- New research on Life Science Research is the subject of a report. According to news reporting from Turku, Finland, by NewsRx journalists, research stated, "Protein-protein interactions drive biological processes. They are critical for all intra-and extracellular functions, and the technologies to analyze them are widely applied throughout the various fields of biological sciences."

The news correspondents obtained a quote from the research from the University of Turku, "This study takes an in-depth view of some common principles of cellular regulation and provides a detailed account of approaches required to comprehensively map signaling protein-protein interactions in any particular cellular system or condition. We provide a critical review of the benefits and disadvantages of the yeast two-hybrid method and affinity purification coupled with mass spectrometric procedures for identification of signaling protein-protein interactions. In particular, we emphasize the quantitative and qualitative differences between tandem affinity and one-step purification (such as FLAG and Strep tag) methods. Although applicable to all types of interaction studies, a special section is devoted in this review to aspects that should be considered when attempting to identify signaling protein interactions that often are transient and weak by nature."

According to the news reporters, the research concluded: "Finally, we discuss shotgun and quantitative information that can be gleaned by MS-coupled methods for analysis of multiprotein complexes."

For more information on this research see: Identification of protein interactions involved in cellular signaling. Molecular and Cellular Proteomics, 2013;12(7):1752-63. (American Society for Biochemistry and Molecular Biology - www.asbmb.org; Molecular and Cellular Proteomics - www.mcponline.org/)

Our news journalists report that additional information may be obtained by contacting J. Westermarck, Centre for Biotechnology, University of Turku and Abo Akademi, Turku, Finland. Additional authors for this research include J. Ivaska and G.L Corthals (see also Life Science Research).

Keywords for this news article include: Turku, Europe, Finland, Life Science Research.

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Life Science Weekly


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