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Study Results from Massachusetts Institute of Technology Broaden Understanding of Thrombosis (Nanoparticles that sense thrombin activity as synthetic...

July 14, 2014



Study Results from Massachusetts Institute of Technology Broaden Understanding of Thrombosis (Nanoparticles that sense thrombin activity as synthetic urinary biomarkers of thrombosis)

By a News Reporter-Staff News Editor at Hematology Week -- Current study results on Cardiovascular Diseases and Conditions have been published. According to news reporting from Cambridge, Massachusetts, by NewsRx journalists, research stated, "Thrombin is a serine protease and regulator of hemostasis that plays a critical role in the formation of obstructive blood clots, or thrombosis, that is a life-threatening condition associated with numerous diseases such as atherosclerosis and stroke. To detect thrombi in living animals, we design and conjugate thrombin-sensitive peptide substrates to the surface of nanoparticles."

The news correspondents obtained a quote from the research from the Massachusetts Institute of Technology, "Following intravenous infusion, these 'synthetic biomarkers' survey the host vasculature for coagulation and, in response to substrate cleavage by thrombin, release ligand-encoded reporters into the host urine. To detect the urinary reporters, we develop a companion 96-well immunoassay that utilizes antibodies to bind specifically to the ligands, thus capturing the reporters for quantification. Using a thromboplastin-induced mouse model of pulmonary embolism, we show that urinary biomarker levels differentiate between healthy and thrombotic states and correlate closely with the aggregate burden of clots formed in the lungs."

According to the news reporters, the research concluded: "Our results demonstrate that synthetic biomarkers can be engineered to sense vascular diseases remotely from the urine and may allow applications in point-of-care diagnostics."

For more information on this research see: Nanoparticles that sense thrombin activity as synthetic urinary biomarkers of thrombosis. Acs Nano, 2013;7(10):9001-9. (American Chemical Society - www.acs.org; Acs Nano - www.pubs.acs.org/journal/ancac3)

Our news journalists report that additional information may be obtained by contacting K.Y. Lin, Dept. of Chemical Engineering, Massachusetts Institute of Technology , Cambridge, Massachusetts 02139, United States. Additional authors for this research include G.A. Kwong, A.D. Warren, D.K. Wood and S.N Bhatia (see also Cardiovascular Diseases and Conditions).

Keywords for this news article include: Cambridge, Hematology, Thrombosis, Nanoparticle, Massachusetts, United States, Nanotechnology, Emerging Technologies, North and Central America, Cardiovascular Diseases and Conditions.

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Hematology Week


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