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Study Data from Sun Yat-Sen University Update Understanding of Extracellular Matrix Proteins (Cell-based assay system to estimate the effect of 125I...

July 18, 2014



Study Data from Sun Yat-Sen University Update Understanding of Extracellular Matrix Proteins (Cell-based assay system to estimate the effect of 125I seeds on cancer cells: effect of osteopontin)

By a News Reporter-Staff News Editor at Drug Week -- Data detailed on Proteins have been presented. According to news reporting out of Guangdong, People's Republic of China, by NewsRx editors, research stated, "A number of recent patents related to 125I seed and osteopontin have been awarded. In this study, we developed a new in vitro model to study the radiobiological effects of 125I seeds on cancer cells."

Our news journalists obtained a quote from the research from Sun Yat-Sen University, "We placed 125I seeds in a cell culture plate with cells seeded on a transwell chamber to evaluate the effects of 125I seeds on cell motility. We placed 125I seeds in a transwell chamber with cells seeded on the cell culture plate to study cell proliferation, apoptosis, and to perform western blot. We used SK-Hep-1 liver cancer cells to evaluate the effectiveness of our model, and investigated the role of osteopontin in the therapeutic effects of 125I seeds. We found that 125I seeds inhibited the cell proliferation and motility in this model while osteopontin reduced these effects. We also measured the effects of 125I seeds on apoptosis. Furthermore, when treated with 125I seeds, we detected changes in several signaling pathways that are involved in the proliferation and invasion of cancer cells. The model can be used to assess the biological effects of 125I seeds in vitro."

According to the news editors, the research concluded: "Osteopontin may be involved in the 125I seed-induced inhibition of SK-Hep-1 cells."

For more information on this research see: Cell-based assay system to estimate the effect of 125I seeds on cancer cells: effect of osteopontin. Recent Patents On Anti-cancer Drug Discovery, 2014;9(2):258-63. (Bentham Science Publishers - www.benthamscience.com; Recent Patents On Anti-cancer Drug Discovery - www.benthamscience.com/pra/index.htm)

Our news journalists report that additional information may be obtained by contacting G. Yang, State Key Laboratory of Oncology in South China, Dept. of Imaging and Interventional Radiology, Cancer Center, Sun Yat-Sen University, Guangzhou, Guangdong 510060, People's Republic of China. Additional authors for this research include S. Peng, Y. Zhang, Z. Liu, M. Lu, T. Zhang, F. Gao and F. Zhang (see also Proteins).

Keywords for this news article include: Asia, Guangdong, Cytokines, Osteopontin, People's Republic of China, Extracellular Matrix Proteins.

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Drug Week


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