Study Data from Shanghai Jiao-Tong University Update Knowledge of Cardiovascular Research (Fabrication of a novel polymer-free nanostructured drug-eluting coating for cardiovascular stents)
By a News Reporter-Staff News Editor at Cardiovascular Week -- Current study results on Cardiovascular Research have been published. According to news reporting originating from Shanghai, People's Republic of China, by NewsRx correspondents, research stated, "Angioplasty with stents is the most important method for the treatment of coronary artery disease (CAD). However, the drug-eluting stents (DES) that are widely used have the increased risks of inflammatory reactions and late stent thrombosis (LST) because of the persistence of the polymer coatings."
Our news editors obtained a quote from the research from Shanghai Jiao-Tong University, "To improve the biosafety, a novel polymer-free-composite drug-eluting coating composed of magnetic mesoporous silica nanoparticles (MMSNs) and carbon nanotubes (CNTs) was constructed using the electrophoretic deposition (EPD) method in this study. A crack-free two-layered coating with impressive network nanotopologies was successfully obtained by regulating the composition and structures. This nanostructured coating exhibits excellent mechanical flexibility and blood compatibility in vitro, and the drug-loading and release performance is satisfactory as well. The in vivo study shows that this composite coating has the obvious advantage of rapid endothelialization because of its unique 3D nanostructured topology in comparison with the commercial polymer-coated DES."
According to the news editors, the research concluded: "This study aims to provide new ideas and reliable data to design novel functional coatings that could accelerate the re-endothelialization process and avoid inflammatory reactions, thus improving the in vivo biosafety of DES."
For more information on this research see: Fabrication of a novel polymer-free nanostructured drug-eluting coating for cardiovascular stents. Acs Applied Materials & Interfaces, 2013;5(20):10337-45. (American Chemical Society - www.acs.org; Acs Applied Materials & Interfaces - www.pubs.acs.org/journal/aamick)
The news editors report that additional information may be obtained by contacting Y. Wang, Nano Biomedical Research center, School of Biomedical Engineering and Med-X Research Institute, Shanghai Jiao Tong University , Shanghai 200030, People's Republic of China. Additional authors for this research include W. Zhang, J. Zhang, W. Sun, R. Zhang and H. Gu (see also Cardiovascular Research).
Keywords for this news article include: Asia, Shanghai, Cardiology, Cardiovascular Research, People's Republic of China.
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