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Study Data from China Pharmaceutical University Update Understanding of Pharmacokinetics (Pharmacokinetics, Tissue Distribution, Excretion and Plasma...

July 16, 2014



Study Data from China Pharmaceutical University Update Understanding of Pharmacokinetics (Pharmacokinetics, Tissue Distribution, Excretion and Plasma Protein Binding Studies of Wogonin in Rats)

By a News Reporter-Staff News Editor at Biotech Week -- Researchers detail new data in Pharmacokinetics. According to news reporting from Jiangsu, People's Republic of China, by NewsRx journalists, research stated, "Wogonin is a natural anticancer candidate. The purpose of this study was to explore the pharmacokinetic profiles, tissue distribution, excretion and plasma protein binding of wogonin in Sprague-Dawley rats."

The news correspondents obtained a quote from the research from China Pharmaceutical University, "A rapid, sensitive, and specific LC-MS/MS method has been developed for the determination of wogonin in different rat biological samples. After i.v. dosing of wogonin at different levels (10, 20 and 40 mg/kg) the elimination half-life was approximately 14 min, the AUC(0-infinity) increased in a dose disproportional manner from 112.13 mg/L.min for 10 mg/kg to 758.19 mg/L.min for 40 mg/kg, indicating a non linear pharmacokinetic profile. After i.g. dosing at 100 mg/kg, plasma levels of wogonin peaked at 28 min with a C-max value of 300 ng/mL and a very low oral bioavailability (1.10%). Following i.v. single dose (20 mg/kg), wogonin was detected in all examined tissues (including testis) with the highest levels in kidney and liver. Approximately 21% of the administered dose was excreted as unchanged drug (mainly via non-biliairy fecal route (16.33%). Equilibrium dialysis was used to evaluate plasma protein binding of wogonin at three concentrations (0.1, 0.5 and 2 mu g/mL)."

According to the news reporters, the research concluded: "Results indicated a very high protein binding degree (over 90%), reducing substantially the free fraction of the compound."

For more information on this research see: Pharmacokinetics, Tissue Distribution, Excretion and Plasma Protein Binding Studies of Wogonin in Rats. Molecules, 2014;19(5):5538-5549. Molecules can be contacted at: Mdpi Ag, Postfach, Ch-4005 Basel, Switzerland. (Springer - www.springer.com; Molecules - www.springerlink.com/content/1420-3049/)

Our news journalists report that additional information may be obtained by contacting A. Talbi, China Pharmaceutical University, Center Drug Metab & Pharmacokinet, Nanjing 210009, Jiangsu, People's Republic of China. Additional authors for this research include D. Zhao, Q.W. Liu, J.X. Li, A. Fan, W. Yang, X. Han and X.J. Chen (see also Pharmacokinetics).

Keywords for this news article include: Asia, Pharmaceuticals, Drugs, Jiangsu, Therapy, Pharmacokinetics, People's Republic of China

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Biotech Week


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