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Studies from Hebrew University Have Provided New Information about DNA Research (DNA nanotechnology: from sensing and DNA machines to drug-delivery...

July 16, 2014

Studies from Hebrew University Have Provided New Information about DNA Research (DNA nanotechnology: from sensing and DNA machines to drug-delivery systems)

By a News Reporter-Staff News Editor at Biotech Week -- Researchers detail new data in DNA Research. According to news reporting originating from Jerusalem, Israel, by NewsRx correspondents, research stated, "DNA/nanoparticle hybrid systems combine the unique electronic and optical properties of nanomaterials with the recognition and catalytic properties of nucleic acids. These materials hold great promise for the development of new sensing platforms, the programmed organization of nanoparticles, the switchable control of plasmonic phenomena in the nanostructures, and the controlled delivery of drugs."

Our news editors obtained a quote from the research from Hebrew University, "In this Perspective, we summarize recent advances in the application of DNA/nanoparticle (NP) hybrids in these different disciplines. Nucleic acid-semiconductor quantum dot hybrids are implemented to develop multiplexed sensing platforms for targeted DNA. The chemiluminescence resonance energy transfer mechanism is introduced as a new transduction signal, and the amplified detection of DNA targets through the biocatalytic regeneration of analytes is demonstrated. DNA machines consisting of catenanes or tweezers, and modified with fluorophore/Au NP pairs are used as functional devices for the switchable 'mechanical' control of the fluorescence properties of the fluorophore. Also, nucleic acid nanostructures act as stimuli-responsive caps for trapping drugs in the pores of mesoporous SiO2 nanoparticles. In the presence of appropriate biomarker triggers, the pores are unlocked, leading to the controlled release of anticancer drugs."

According to the news editors, the research concluded: "Selective cancer-cell death is demonstrated with the stimuli-responsive SiO2 nanoparticles."

For more information on this research see: DNA nanotechnology: from sensing and DNA machines to drug-delivery systems. Acs Nano, 2013;7(10):8320-32. (American Chemical Society -; Acs Nano -

The news editors report that additional information may be obtained by contacting C.H. Lu, Institute of Chemistry and The Center for Nanoscience and Nanotechnology, The Hebrew University of Jerusalem , Jerusalem 91904, Israel. Additional authors for this research include B. Willner and I. Willner (see also DNA Research).

Keywords for this news article include: Asia, Israel, Therapy, Jerusalem, DNA Research, Nanoparticle, Nanostructural, Nanostructures, Nanotechnology, Drug Delivery Systems, Emerging Technologies.

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC

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Source: Biotech Week

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