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Studies from Gifu University Yield New Data on Melanomas (Synthesized quercetin derivatives stimulate melanogenesis in B16 melanoma cells by...

July 18, 2014



Studies from Gifu University Yield New Data on Melanomas (Synthesized quercetin derivatives stimulate melanogenesis in B16 melanoma cells by influencing the expression of melanin biosynthesis proteins MITF and p38 MAPK)

By a News Reporter-Staff News Editor at Health & Medicine Week -- Investigators publish new report on Melanomas. According to news reporting originating in Gifu, Japan, by NewsRx journalists, research stated, "In order to understand the effect of structure-activity relationships on melanogenesis using B16 melanoma cells, 19 quercetin derivatives were synthesized. Among the synthesized compounds, 3-O-methylquercetin (11) and 3',4',7-O-trimethylquercetin (14) increased melanin content more potently than the positive control theophylline, while exhibiting low cytotoxicity."

The news reporters obtained a quote from the research from Gifu University, "Compound 11 exhibited less melanogenesis-stimulating activity than compound 14. However, 11 increased the expression of tyrosinase and tyrosinase-related protein 1 (TRP-1) to a greater extent than 14, thereby suggesting that melanogenesis in melanoma cells does not depend solely on the expression of the enzymes catalyzing melanin biosynthesis. Furthermore, 14 also stimulated the expression of the microphthalmia-associated transcription factor (MITF) and p-p38 mitogen activated protein kinase (MAPK), while they were not increased by 11."

According to the news reporters, the research concluded: "These results suggest that 11 may enhance the expression of tyrosinase and TRP-1 by regulating the proteasomal degradation of melanogenic enzymes and/or by activating other transcriptional factors regulating enzyme expression."

For more information on this research see: Synthesized quercetin derivatives stimulate melanogenesis in B16 melanoma cells by influencing the expression of melanin biosynthesis proteins MITF and p38 MAPK. Bioorganic & Medicinal Chemistry, 2014;22(13):3331-3340. Bioorganic & Medicinal Chemistry can be contacted at: Pergamon-Elsevier Science Ltd, The Boulevard, Langford Lane, Kidlington, Oxford OX5 1GB, England. (Elsevier - www.elsevier.com; Bioorganic & Medicinal Chemistry - www.elsevier.com/wps/product/cws_home/129)

Our news correspondents report that additional information may be obtained by contacting K. Yamauchi, Gifu University, United Grad Sch Agr Sci, Gifu 5011193, Japan. Additional authors for this research include T. Mitsunaga, M. Inagaki and T. Suzuki (see also Melanomas).

Keywords for this news article include: Gifu, Asia, Japan, Melanomas, Tyrosinase, Enzymes and Coenzymes

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Health & Medicine Week


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