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Studies from Columbia University Reveal New Findings on Enzymes and Coenzymes (Origins of activity enhancement in enzyme cascades on scaffolds)

July 15, 2014

By a News Reporter-Staff News Editor at Life Science Weekly -- Current study results on Enzymes and Coenzymes have been published. According to news reporting originating from New York City, New York, by NewsRx correspondents, research stated, "The concept of 'metabolic channeling' as a result of rapid transfer of freely diffusing intermediate substrates between two enzymes on nanoscale scaffolds is examined using simulations and mathematical models. The increase in direct substrate transfer due to the proximity of the two enzymes provides an initial but temporary boost to the throughput of the cascade and loses importance as product molecules of enzyme 1 (substrate molecules of enzyme 2) accumulate in the surrounding container."

Our news editors obtained a quote from the research from Columbia University, "The characteristic time scale at which this boost is significant is given by the ratio of container volume to the product of substrate diffusion constant and interenzyme distance and is on the order of milliseconds to seconds in some experimental systems. However, the attachment of a large number of enzyme pairs to a scaffold provides an increased number of local 'targets', extending the characteristic time. If substrate molecules for enzyme 2 are sequestered by an alternative reaction in the container, a scaffold can result in a permanent boost to cascade throughput with a magnitude given by the ratio of the above-defined time scale to the lifetime of the substrate molecule in the container. Finally, a weak attractive interaction between substrate molecules and the scaffold creates a 'virtual compartment' and substantially accelerates initial throughput."

According to the news editors, the research concluded: "If intermediate substrates can diffuse freely, placing individual enzyme pairs on scaffolds is only beneficial in large cells, unconfined extracellular spaces or in systems with sequestering reactions."

For more information on this research see: Origins of activity enhancement in enzyme cascades on scaffolds. Acs Nano, 2013;7(10):8658-65. (American Chemical Society -; Acs Nano -

The news editors report that additional information may be obtained by contacting O. Idan, Dept. of Biomedical Engineering, Columbia University , New York, New York 10027, United States (see also Enzymes and Coenzymes).

Keywords for this news article include: New York City, United States, Enzymes and Coenzymes, North and Central America.

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Source: Life Science Weekly

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