News Column

Researchers Submit Patent Application, "Transportation Device", for Approval

July 16, 2014



By a News Reporter-Staff News Editor at Vaccine Weekly -- From Washington, D.C., NewsRx journalists report that a patent application by the inventors CHEN, Chien-Lung (New Taipei City, TW); CHEN, Cheng-Hsien (Taipei City, TW); WU, Chang-Jer (Taipei City, TW); HUANG, Han-Ning (Taipei City, TW), filed on February 26, 2014, was made available online on July 3, 2014 (see also Patents).

The patent's assignee is Chen; Chien-Lung.

News editors obtained the following quote from the background information supplied by the inventors: "This invention related to a transportation device which transfers the material to cells by physical method.

"There are lots of ways to deliver bio-materials or medicines into cells even through skin, including using physical theorem, mechanical theorem or both of them. For instances, popular ways to administer bio-materials or medicines includes electroporation, microinjection, and the likes. But these physical injection ways are difficult to operate, and the stability and the rate of success are poor. Therefore, they are not widely used in this field. On the other hand, the research of gene guns reveals the potential for physical bio-materials or medicines transferring technique.

"The method of using a gene gun is carrying the vectors (e.g. gold particles) of bio-materials (e.g. DNA) into cells by high-speed shooting for achieving gene transferring. And this technique is already extensively applied into many research fields which include plant system, cells of mammal, gene therapy, and the latest deoxyribonucleic acid (DNA) vaccine study systems as well.

"For instance, the gene gun can carry gold particles mixed with DNA, put them on a cartridge, and generate seismic waves by using twinkling high-pressure stream so that the cartridge will accelerate until reaching an obstruction. Because the gold particles in the cartridge, will keep moving in a high speed due to inertia, it will enter into cells. However, the drawback of this gene gun is too noisy, and the seismic waves could kill target cells easily. This gene gun also needs to consume a large amount of expensive helium and vectors (usually gold particles).

"Besides, there is another way to provide medicine by a gene gun with low pressure vapor acceleration which carries the liquid (suspension liquid with nanometer particles) with DNA to be injected into a converging-diverging nozzle directly or indirectly, and then carries the liquid into human body through the spray nozzle by the instant low pressure vapor. Although this type of gene gun is able to overcome the existing bottleneck, however, as to the existing gene gun, before the sample entering the nozzle, it forms a turbulent flow so the sample may easily have collisions with the wall and be condensed on the wall surface. Additionally, the structure design of the nozzle itself has blind angle. At the same time, low-pressure gas provides the lower kinetic energy, which can not affect the residual sample on the wall to bring it out. For the low-pressure gas accelerating gene gun, its worst drawback is that the liquid is easy to remain in the nozzle which leads to the problems of quantitative and continuous operation.

"Therefore, it is an important subjective to provide a transportation device to solve existing bottlenecks encountered."

As a supplement to the background information on this patent application, NewsRx correspondents also obtained the inventors' summary information for this patent application: "In view of the foregoing, an objective of the present invention is to provide a transportation device having the physical design of drug delivery systems based on the fluid mechanics theory for delivering the mixed material and carrier fluid to a target.

"To achieve the above objective, the present invention discloses a transportation device, which can physically transport a material to a target.

"The transportation device includes an input module, a transmission module and an output module.

"The input module comprising a containing unit and at least one filter. The at least one filter is connected to the containing unit, and a carrier fluid that stored in the containing unit.

"The transmission module is coupled to the input module. The carrier fluid and the material go through the filter and then enter the transmission module. The input module and the transmission module form at least one transmission path accordingly.

"The output module has a guiding unit, a first opening, a second opening, and a throat portion positioned between the first and second openings. One end of the guiding unit is connected to the transmission module, and the other end of the guiding unit comprising a guiding corner for connecting to the first opening. The material enters the input module through the first opening and then reaches the target through the second opening.

"As mentioned above, in some embodiments the transportation device of the present invention may change the fluid (including: liquid, gas, gel, etc.) size by the atomizing unit. At the same time, through a mixing unit, the atomized material or the solid particles less than 500 microns can be mixed within the carrier fluid. With applying a certain pressure (e.g. 10kg/cm.sup.2) in the output module, a very high-speed fluid can be generated, so that the carrier fluid and the material can be well mixed.

"The temperature inside the output module may down to below zero in a fast moment, so the mixed two-phase samples can be accelerated to high speed and have instantaneous phase change (liquid to solid phase change, which includes ice crystals, ice needles, and the likes).

"After he solid material is transferred to the second opening, at least a part of the solid material has phase change from solid phase to liquid phase. The liquid phase material can help to reach the surface of the targets, and the solid phase material can make it easier to enter the target (e.g. enter cells through the biological or cell surfaces), thereby achieving the purpose of transmission.

"Compared with the prior art, this invention not only enhances the use of convenience of those liquid containing biological material (such as DNA, RNA, proteins, viruses, physical, chemical drugs, etc.) or solid state within 500 microns, but also can reduce the difficulty of coping and producing traditional carriers (gold grains) which could reduce the destruction to the biological material and injury to the target (for example: the target cell), and also improve the safety of using and reliable possibility. Moreover, the present invention can also control the amount of the material transferred into the target so as to enhance the dosage control.

BRIEF DESCRIPTION OF THE DRAWINGS

"The invention will become more fully understood from the detailed description and accompanying drawings, which are given for illustration only, and thus are not limitative of the present invention, and wherein:

"FIG. 1 is a diagram showing a transportation device according to an embodiment of the invention;

"FIG. 2 is a diagram showing the structure of the guiding unit and the output module of the transportation device of the invention;

"FIG. 3 is diagram showing the temperature-gradient inside the output module;

"FIG. 4 is a diagram showing a transportation device according to another embodiment of the invention;

"FIG. 5 is a diagram showing the transportation device used for solid material;

"FIG. 6A is diagram showing the internal structure of a mixing unit of the transportation device used for solid material;

"FIG. 6B is diagram showing the internal structure of a mixing unit of the transportation device used for non-solid material;

"FIG. 7 is a diagram showing the transportation device used for non-solid material;

"FIG. 8 is a diagram showing the internal structure of the transportation device, wherein the atomizing unit is an electrical-oscillated atomizer;

"FIG. 9 is a diagram showing the internal structure of the transportation device, wherein the atomizing unit is a twin-fluid atomizer;

"FIG. 10 is a diagram showing the internal structure of the transportation device, wherein the atomizing unit is a parallel-type twin-fluid atomizer;

"FIG. 11 is a diagram showing the internal structure of the transportation device, wherein the atomizing unit is a vertical-type twin-fluid atomizer; and

"FIG. 12 is a diagram showing the internal structure of the transportation device, wherein the atomizing unit is a hydraulic atomizer."

For additional information on this patent application, see: CHEN, Chien-Lung; CHEN, Cheng-Hsien; WU, Chang-Jer; HUANG, Han-Ning. Transportation Device. Filed February 26, 2014 and posted July 3, 2014. Patent URL: http://appft.uspto.gov/netacgi/nph-Parser?Sect1=PTO2&Sect2=HITOFF&u=%2Fnetahtml%2FPTO%2Fsearch-adv.html&r=3064&p=62&f=G&l=50&d=PG01&S1=20140626.PD.&OS=PD/20140626&RS=PD/20140626

Keywords for this news article include: Patents, DNA Research.

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Vaccine Weekly


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