Researchers from University of Naples Federico II Provide Details of New Studies and Findings in the Area of Cancer Gene Therapy (5-HT1A Receptor: An Old Target as a New Attractive Tool in Drug Discovery from Central Nervous System to Cancer)
By a News Reporter-Staff News Editor at Cancer Gene Therapy Week -- Current study results on Biotechnology have been published. According to news reporting originating from Naples, Italy, by NewsRx correspondents, research stated, "The serotonin receptor subtype 5-HT1A was one of the first serotonin receptor subtypes pharmacologically characterized. This receptor subtype has long been object of intense research and is implicated in the pathogenesis and treatment of anxiety and depressive disorders."
Our news editors obtained a quote from the research from the University of Naples Federico II, "In recent years, new chemical entities targeting the 5-HT1A receptor (alone or in combination with other molecular targets) have been proposed for novel therapeutic uses in neuroprotection, cognitive impairment, Parkinson's disease, pain treatment, malignant carcinoid syndrome, and prostate cancer. This Perspective compares existing data on expression and signaling activity of the 5-HT1A receptor to a ligand with an intrinsic agonist or antagonist profile. Our purpose is also to make a complete overview, useful for underlining the features needed to select a specific pharmacological profile rather than another one."
According to the news editors, the research concluded: "This aspect could be really interesting to consider and justify the 5-HT1A receptor as a new attractive target for drug discovery."
For more information on this research see: 5-HT1A Receptor: An Old Target as a New Attractive Tool in Drug Discovery from Central Nervous System to Cancer. Journal of Medicinal Chemistry, 2014;57(11):4407-4426. Journal of Medicinal Chemistry can be contacted at: Amer Chemical Soc, 1155 16TH St, NW, Washington, DC 20036, USA. (American Chemical Society - www.acs.org; Journal of Medicinal Chemistry - www.pubs.acs.org/journal/jmcmar)
The news editors report that additional information may be obtained by contacting F. Fiorino, University of Naples Federico II, Dipartimento Farm, I-80131 Naples, Italy. Additional authors for this research include B. Severino, E. Magli, A. Ciano, G. Caliendo, V. Santagada, F. Frecentese and E. Perissutti (see also Biotechnology).
Keywords for this news article include: Biotechnology, Italy, Naples, Europe, Oncology, Autacoids, Serotonin, Cancer Gene Therapy, Central Nervous System Disorders
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