News Column

Researchers from University of Chicago Report Recent Findings in Cancer Gene Therapy (The impact of microRNA expression on cellular proliferation)

July 14, 2014



By a News Reporter-Staff News Editor at Cancer Gene Therapy Week -- Investigators publish new report on Biotechnology. According to news reporting originating in Chicago, Illinois, by NewsRx journalists, research stated, "As an important class of non-coding regulatory RNAs, microRNAs (miRNAs) play a key role in a range of biological processes. These molecules serve as post-transcriptional regulators of gene expression and their regulatory activity has been implicated in disease pathophysiology and pharmacological traits."

The news reporters obtained a quote from the research from the University of Chicago, "We sought to investigate the impact of miRNAs on cellular proliferation to gain insight into the molecular basis of complex traits that depend on cellular growth, including, most prominently, cancer. We examined the relationship between miRNA expression and intrinsic cellular growth (iGrowth) in the HapMap lymphoblastoid cell lines derived from individuals of different ethnic backgrounds. We found a substantial enrichment for miRNAs (53 miRNAs, FDR < 0.05) correlated with cellular proliferation in pooled CEU (Caucasian of northern and western European descent) and YRI (individuals from Ibadan, Nigeria) samples. Specifically, 119 miRNAs (59 %) were significantly correlated with iGrowth in YRI; of these miRNAs, 18 were correlated with iGrowth in CEU. To gain further insight into the effect of miRNAs on cellular proliferation in cancer, we showed that over-expression of miR-22, one of the top iGrowth-associated miRNAs, leads to growth inhibition in an ovarian cancer cell line (SKOV3). Furthermore, over-expression of miR-22 down-regulates the expression of its target genes (MXI1 and SLC25A37) in this ovarian cancer cell line, highlighting an miRNA-mediated regulatory network potentially important for cellular proliferation."

According to the news reporters, the research concluded: "Importantly, our study identified miRNAs that can be used as molecular targets in cancer therapy."

For more information on this research see: The impact of microRNA expression on cellular proliferation. Human Genetics, 2014;133(7):931-938. Human Genetics can be contacted at: Springer, 233 Spring St, New York, NY 10013, USA. (Springer - www.springer.com; Human Genetics - www.springerlink.com/content/0340-6717/)

Our news correspondents report that additional information may be obtained by contacting D. Lenkala, University Chicago, Dept. of Hlth Studies, Chicago, IL 60637, United States. Additional authors for this research include B. LaCroix, E.R. Gamazon, P. Geeleher, H.K. Im and R.S. Huang (see also Biotechnology).

Keywords for this news article include: Biotechnology, Chicago, Illinois, Genetics, Oncology, United States, Cancer Gene Therapy, North and Central America

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Cancer Gene Therapy Week


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