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Researchers from Aichi Institute of Technology Detail Findings in Genetics and Autoimmune Diseases (Activation of the STING Adaptor Attenuates...

July 16, 2014

Researchers from Aichi Institute of Technology Detail Findings in Genetics and Autoimmune Diseases (Activation of the STING Adaptor Attenuates Experimental Autoimmune Encephalitis)

By a News Reporter-Staff News Editor at Biotech Week -- Current study results on Immune System Diseases and Conditions have been published. According to news reporting from Toyota, Japan, by NewsRx journalists, research stated, "Cytosolic DNA sensing activates the stimulator of IFN genes (STING) adaptor to induce IFN type I (IFN-alpha beta) production. Constitutive DNA sensing to induce sustained STING activation incites tolerance breakdown, leading to autoimmunity."

The news correspondents obtained a quote from the research from the Aichi Institute of Technology, "In this study, we show that systemic treatments with DNA nanoparticles (DNPs) induced potent immune regulatory responses via STING signaling that suppressed experimental autoimmune encephalitis (EAE) when administered to mice after immunization with myelin oligodendrocyte glycoprotein (MOG), at EAE onset, or at peak disease severity. DNP treatments attenuated infiltration of effector T cells into the CNS and suppressed innate and adaptive immune responses to myelin oligodendrocyte glycoprotein immunization in spleen. Therapeutic responses were not observed in mice treated with cargo DNA or cationic polymers alone, indicating that DNP uptake and cargo DNA sensing by cells with regulatory functions was essential for therapeutic responses to manifest. Intact STING and IFN-alpha beta receptor genes, but not IFN-gamma receptor genes, were essential for therapeutic responses to DNPs to manifest. Treatments with cyclic diguanylate monophosphate to activate STING also delayed EAE onset and reduced disease severity. Therapeutic responses to DNPs were critically dependent on IDO enzyme activity in hematopoietic cells. Thus, DNPs and cyclic diguanylate monophosphate attenuate EAE by inducing dominant T cell regulatory responses via the STING/IFN-alpha beta/IDO pathway that suppress CNS-specific autoimmunity."

According to the news reporters, the research concluded: "These findings reveal dichotomous roles for the STING/IFN-alpha beta pathway in either stimulating or suppressing autoimmunity and identify STING-activating reagents as a novel class of immune modulatory drugs."

For more information on this research see: Activation of the STING Adaptor Attenuates Experimental Autoimmune Encephalitis. Journal of Immunology, 2014;192(12):5571-5578. Journal of Immunology can be contacted at: Amer Assoc Immunologists, 9650 Rockville Pike, Bethesda, MD 20814, USA. (The American Association of Immunologists -; Journal of Immunology -

Our news journalists report that additional information may be obtained by contacting H. Lemos, Aichi Inst Technol, Fac Engn, Dept. of Appl Chem, Toyota 4700392, Japan. Additional authors for this research include L. Huang, P.R. Chandler, E. Mohamed, G.R. Souza, L.Q. Li, G. Pacholczyk, G.N. Barber, Y. Hayakawa, D.H. Munn and A.L. Mellor (see also Immune System Diseases and Conditions).

Keywords for this news article include: Asia, Japan, Toyota, Therapy, Genetics, Immunology, DNA Research, Encephalitis, Glycoproteins, Brain Diseases, Virus Diseases, Glycoconjugates, Autoimmune Diseases, Autoimmune Disorders, Central Nervous System Diseases, Central Nervous System Infections, Central Nervous System Viral Diseases

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC

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Source: Biotech Week

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