Researchers at University of Warwick Have Reported New Data on DNA Research ("Giant surfactants" created by the fast and efficient functionalization of a DNA tetrahedron with a temperature-responsive polymer)
By a News Reporter-Staff News Editor at Life Science Weekly -- Researchers detail new data in DNA Research. According to news reporting originating from Coventry, United Kingdom, by NewsRx correspondents, research stated, "Copper catalyzed azide-alkyne cycloaddition (CuAAC) was employed to synthesize DNA block copolymers (DBCs) with a range of polymer blocks including temperature-responsive poly(N-isoproylacrylamide) (poly(NIPAM)) and highly hydrophobic poly(styrene). Exceptionally high yields were achieved at low DNA concentrations, in organic solvents, and in the absence of any solid support."
Our news editors obtained a quote from the research from the University of Warwick, "The DNA segment of the DBC remained capable of sequence-specific hybridization: it was used to assemble a precisely defined nanostructure, a DNA tetrahedron, with pendant poly(NIPAM) segments. In the presence of an excess of poly(NIPAM) homopolymer, the tetrahedron-poly(NIPAM) conjugate nucleated the formation of large, well-defined nanoparticles at 40 °C, a temperature at which the homopolymer precipitated from solution. These composite nanoparticles were observed by dynamic light scattering and cryoTEM, and their hybrid nature was confirmed by AFM imaging."
According to the news editors, the research concluded: "As a result of the large effective surface area of the tetrahedron, only very low concentrations of the conjugate were required in order for this surfactant-like behavior to be observed."
For more information on this research see: "Giant surfactants" created by the fast and efficient functionalization of a DNA tetrahedron with a temperature-responsive polymer. Acs Nano, 2013;7(10):8561-72. (American Chemical Society - www.acs.org; Acs Nano - www.pubs.acs.org/journal/ancac3)
The news editors report that additional information may be obtained by contacting T.R. Wilks, Dept. of Chemistry, University of Warwick , Coventry, West Midlands CV4 7AL, UK. Additional authors for this research include J. Bath, J.W. de Vries, J.E. Raymond, A. Herrmann, A.J. Turberfield and R.K O'Reilly (see also DNA Research).
Keywords for this news article include: Europe, Coventry, DNA Research, Nanoparticle, United Kingdom, Nanotechnology, Emerging Technologies.
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