Researchers at National Institute on Alcohol Abuse and Alcoholism Have Reported New Data on Alcoholism (Coordinated dysregulation of mRNAs and microRNAs in the rat medial prefrontal cortex following a history of alcohol dependence)
By a News Reporter-Staff News Editor at Biotech Week -- New research on Alcoholism is the subject of a report. According to news reporting from Bethesda, Maryland, by NewsRx journalists, research stated, "Long-term changes in brain gene expression have been identified in alcohol dependence, but underlying mechanisms remain unknown. Here, we examined the potential role of microRNAs (miRNAs) for persistent gene expression changes in the rat medial prefrontal cortex (mPFC) after a history of alcohol dependence."
The news correspondents obtained a quote from the research from National Institute on Alcohol Abuse and Alcoholism, "Two-bottle free-choice alcohol consumption increased following 7-week exposure to intermittent alcohol intoxication. A bioinformatic approach using microarray analysis, quantitative PCR (qPCR), bioinformatic analysis and microRNA-messenger RNA (mRNA) integrative analysis identified expression patterns indicative of a disruption in synaptic processes and neuroplasticity. About 41 rat miRNAs and 165 mRNAs in the mPFC were significantly altered after chronic alcohol exposure. A subset of the miRNAs and mRNAs was confirmed by qPCR. Gene ontology categories of differential expression pointed to functional processes commonly associated with neurotransmission, neuroadaptation and synaptic plasticity. microRNA-mRNA expression pairing identified 33 miRNAs putatively targeting 89 mRNAs suggesting transcriptional networks involved in axonal guidance and neurotransmitter signaling. Our results demonstrate a significant shift in microRNA expression patterns in the mPFC following a history of dependence. Owing to their global regulation of multiple downstream target transcripts, miRNAs may have a pivotal role in the reorganization of synaptic connections and long-term neuroadaptations in alcohol dependence."
According to the news reporters, the research concluded: "MicroRNA-mediated alterations of transcriptional networks may be involved in disrupted prefrontal control over alcohol drinking observed in alcoholic patients."
For more information on this research see: Coordinated dysregulation of mRNAs and microRNAs in the rat medial prefrontal cortex following a history of alcohol dependence. The Pharmacogenomics Journal, 2013;13(3):286-96 (see also Alcoholism).
Our news journalists report that additional information may be obtained by contacting J.D. Tapocik, Laboratory of Clinical and Translational Studies, National Institute on Alcohol Abuse and Alcoholism, National Institutes of Health, Bethesda, MD, United States. Additional authors for this research include M. Solomon, M. Flanigan, M. Meinhardt, E. Barbier, J.R. Schank, M. Schwandt, W.H. Sommer and M. Heilig.
Keywords for this news article include: Biotechnology, Bethesda, Maryland, Cerebrum, Alcoholism, Frontal Lobe, United States, Mental Health, Telencephalon, Bioengineering, Prosencephalon, Prefrontal Cortex, Addiction Medicine, Applied Bioinformatics, North and Central America.
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