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Researchers at Jilin University Release New Data on Osteosarcomas (Heme oxygenase-1 silencing increases the sensitivity of human osteosarcoma MG63...

July 16, 2014



Researchers at Jilin University Release New Data on Osteosarcomas (Heme oxygenase-1 silencing increases the sensitivity of human osteosarcoma MG63 cells to arsenic trioxide)

By a News Reporter-Staff News Editor at Biotech Week -- Investigators publish new report on Oncology. According to news originating from Changchun, People's Republic of China, by NewsRx correspondents, research stated, "Arsenic trioxide (ATO) has been successfully used to treat leukemia and some solid malignant tumors. Our previous study regarding the effects of ATO on mesenchymal-derived human osteosarcoma MG63 cells showed that heme oxygenase-1 (HO-1) was strongly induced upon treatment with ATO."

Our news journalists obtained a quote from the research from Jilin University, "The present study sought to investigate the effect of silencing HO-1 on the sensitivity of osteosarcoma cells to ATO to determine the potential for therapeutic applications. Small hairpin RNA (shRNA)-mediated interference was used to silence HO-1 in MG63 cells. Viability, apoptosis, and intracellular reactive oxygen species (ROS) of the cells were assessed to evaluate the sensitivity of the cells to ATO as well as the potential mechanisms responsible. shRNA-mediated interference prevented the induction of HO-1, increased cell death, and increased intracellular ROS levels in MG63 cells upon treatment with ATO. Silencing HO-1 increased the susceptibility of MG63 cells to the chemotherapeutic drug ATO by enhancing intracellular accumulation of ROS."

According to the news editors, the research concluded: "Our results suggest that the inhibition of HO-1 could improve the outcome of osteosarcoma treated with ATO."

For more information on this research see: Heme oxygenase-1 silencing increases the sensitivity of human osteosarcoma MG63 cells to arsenic trioxide. Molecular and Cellular Biochemistry, 2014;392(1-2):135-144. Molecular and Cellular Biochemistry can be contacted at: Springer, Van Godewijckstraat 30, 3311 Gz Dordrecht, Netherlands. (Springer - www.springer.com; Molecular and Cellular Biochemistry - www.springerlink.com/content/0300-8177/)

The news correspondents report that additional information may be obtained from L.Z. Zhong, Jilin University, Norman Bethune Coll Med, Changchun 130021, People's Republic of China. Additional authors for this research include Y. Wang, W.X. Li, J.L. Gu, X.Y. Li, X.T. Wang, Z. Yue, Y. Mu, J.P. Bai, R.G. Li and H.Y. Zhang (see also Oncology).

Keywords for this news article include: Asia, Antineoplastics, Pharmaceuticals, Drugs, Therapy, Oncology, Changchun, Chemicals, Chemistry, Oxygenases, Orthopedics, Osteosarcoma, Oxidoreductases, Arsenic Trioxide, Enzymes and Coenzymes, People's Republic of China

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Biotech Week


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