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Researchers at International Center for Genetic Engineering and Biotechnology Release New Data on Biomolecular Structure and Dynamics (Putative...

July 15, 2014



Researchers at International Center for Genetic Engineering and Biotechnology Release New Data on Biomolecular Structure and Dynamics (Putative osmosensor--OsHK3b--a histidine kinase protein from rice shows high structural conservation with its ...)

By a News Reporter-Staff News Editor at Life Science Weekly -- Current study results on Life Science Research have been published. According to news reporting originating in New Delhi, India, by NewsRx journalists, research stated, "Prokaryotes and eukaryotes respond to various environmental stimuli using the two-component system (TCS). Essentially, it consists of membrane-bound histidine kinase (HK) which senses the stimuli and further transfers the signal to the response regulator, which in turn, regulates expression of various target genes."

The news reporters obtained a quote from the research from International Center for Genetic Engineering and Biotechnology, "Recently, sequence-based genome wide analysis has been carried out in Arabidopsis and rice to identify all the putative members of TCS family. One of the members of this family i.e. AtHK1, (a putative osmosensor, hybrid-type sensory histidine kinase) is known to interact with AtHPt1 (phosphotransfer proteins) in Arabidopsis. Based on predicted rice interactome network (PRIN), the ortholog of AtHK1 in rice, OsHK3b, was found to be interacting with OsHPt2. The analysis of amino acid sequence of AtHK1 showed the presence of transmitter domain (TD) and receiver domain (RD), while OsHK3b showed presence of three conserved domains namely CHASE (signaling domain), TD, and RD. In order to elaborate on structural details of functional domains of hybrid-type HK and phosphotransfer proteins in both these genera, we have modeled them using homology modeling approach. The structural motifs present in various functional domains of the orthologous proteins were found to be highly conserved."

According to the news reporters, the research concluded: "Binding analysis of the RD domain of these sensory proteins in Arabidopsis and rice revealed the role of various residues such as histidine in HPt protein which are essential for their interaction."

For more information on this research see: Putative osmosensor--OsHK3b--a histidine kinase protein from rice shows high structural conservation with its ortholog AtHK1 from Arabidopsis. Journal of Biomolecular Structure & Dynamics, 2014;32(8):1318-32 (see also Life Science Research).

Our news correspondents report that additional information may be obtained by contacting H.R. Kushwaha, a Synthetic Biology and Biofuel Group , International Center for Genetic Engineering and Biotechnology , New Delhi 110067 , India. Additional authors for this research include S.L. Singla-Pareek and A. Pareek.

Keywords for this news article include: Asia, India, Kinase, New Delhi, Enzymes and Coenzymes, Life Science Research.

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Life Science Weekly


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