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Research from Johns Hopkins University School of Medicine Yields New Findings on Molecular Pharmaceutics (Ex vivo characterization of particle...

July 16, 2014



Research from Johns Hopkins University School of Medicine Yields New Findings on Molecular Pharmaceutics (Ex vivo characterization of particle transport in mucus secretions coating freshly excised mucosal tissues)

By a News Reporter-Staff News Editor at Biotech Week -- Investigators publish new report on Biotechnology. According to news originating from Baltimore, Maryland, by NewsRx correspondents, research stated, "Sustained drug delivery to mucosal surfaces has the potential to improve the effectiveness of prophylactic and therapeutic treatments for numerous diseases and conditions, including inflammatory bowel disease, sexually transmitted diseases, cystic fibrosis, glaucoma, dry eye, and various cancers. Sustained delivery systems such as nanoparticles can be useful for mucosal delivery, but recent work suggests they must penetrate the rapidly cleared mucus barrier that overlies all mucosal epithelia to achieve uniform distribution on epithelial surfaces and enhanced residence time."

Our news journalists obtained a quote from the research from the Johns Hopkins University School of Medicine, "Thus, it is important to evaluate the mucus-penetrating ability of nanosized delivery systems in preclinical animal studies, and for administration to humans. We describe a simple ex vivo method to visualize and quantify nanoparticle transport in mucus on fresh mucosal tissues."

According to the news editors, the research concluded: "Using this method in murine models, we observed variations in the mucus mesh at different anatomical locations, as well as cyclical variations that may have implications for mucosal delivery."

For more information on this research see: Ex vivo characterization of particle transport in mucus secretions coating freshly excised mucosal tissues. Molecular Pharmaceutics, 2013;10(6):2176-82. (American Chemical Society - www.acs.org; Molecular Pharmaceutics - www.pubs.acs.org/journal/mpohbp)

The news correspondents report that additional information may be obtained from L.M. Ensign, Center for Nanomedicine, The Wilmer Eye Institute, Johns Hopkins University School of Medicine, Baltimore, Maryland 21231, United States. Additional authors for this research include A. Henning, C.S. Schneider, K. Maisel, Y.Y. Wang, M.D. Porosoff, R. Cone and J. Hanes (see also Biotechnology).

Keywords for this news article include: Biotechnology, Maryland, Baltimore, United States, North and Central America.

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Biotech Week


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