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Research Data from Soochow University Update Understanding of Quantum Dots (DNA-Templated Assembly of a Heterobivalent Quantum Dot Nanoprobe For...

July 15, 2014



Research Data from Soochow University Update Understanding of Quantum Dots (DNA-Templated Assembly of a Heterobivalent Quantum Dot Nanoprobe For Extra- and Intracellular Dual-Targeting and Imaging of Live Cancer Cells)

By a News Reporter-Staff News Editor at Cancer Weekly -- Current study results on Quantum Dots have been published. According to news reporting originating in Suzhou, People's Republic of China, by NewsRx journalists, research stated, "Quantum dots (QDs) hold great promise for the molecular imaging of cancer because of their superior optical properties. Although cell-surface biomarkers can be readily imaged with QDs, non-invasive live-cell imaging of critical intracellular cancer markers with QDs is a great challenge because of the difficulties in the automatic delivery of QD probes to the cytosol and the ambiguity of intracellular targeting signals."

The news reporters obtained a quote from the research from Soochow University, "Herein, we report a new type of DNA-templated heterobivalent QD nanoprobes with the ability to target and image two spatially isolated cancer markers (nucleolin and mRNA) present on the cell surface and in the cell cytosol. Bypassing endolysosomal sequestration, this type of QD nanoprobes undergo macropinocytosis following the nucleolin targeting and then translocate to the cytosol for mRNA targeting."

According to the news reporters, the research concluded: "Fluorescence resonance energy transfer (FRET) based confocal microscopy enables unambiguous signal deconvolution of mRNA-targeted QD nanoprobes inside cancer cells."

For more information on this research see: DNA-Templated Assembly of a Heterobivalent Quantum Dot Nanoprobe For Extra- and Intracellular Dual-Targeting and Imaging of Live Cancer Cells. Angewandte Chemie-International Edition, 2014;53(22):5573-5577. Angewandte Chemie-International Edition can be contacted at: Wiley-V C H Verlag Gmbh, Boschstrasse 12, D-69469 Weinheim, Germany (see also Quantum Dots).

Our news correspondents report that additional information may be obtained by contacting W. Wei, Soochow Univ, Coll Chem Chem Engn & Mat Sci, Key Lab Hlth Chem & Mol Diag Suzhou, Suzhou 215123, People's Republic of China. Additional authors for this research include X.W. He and N. Ma.

Keywords for this news article include: Asia, Suzhou, Cancer, Oncology, Quantum Dots, Nanotechnology, Emerging Technologies, People's Republic of China

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Cancer Weekly


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