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Research Conducted by C. Rodrigues and Co-Researchers Has Updated Our Knowledge about Stem Cells (New therapy of skin repair combining...

July 16, 2014



Research Conducted by C. Rodrigues and Co-Researchers Has Updated Our Knowledge about Stem Cells (New therapy of skin repair combining adipose-derived mesenchymal stem cells with sodium carboxymethylcellulose scaffold in a pre-clinical rat model)

By a News Reporter-Staff News Editor at Biotech Week -- Investigators discuss new findings in Stem Cell Research. According to news reporting originating from Porto Alegre, Brazil, by NewsRx correspondents, research stated, "Lesions with great loss of skin and extensive burns are usually treated with heterologous skin grafts, which may lead rejection. Cell therapy with mesenchymal stem cells is arising as a new proposal to accelerate the healing process."

Our news editors obtained a quote from the research, "We tested a new therapy consisting of sodium carboxymethylcellulose (CMC) as a biomaterial, in combination with adipose-derived stem cells (ADSCs), to treat skin lesions in an in vivo rat model. This biomaterial did not affect membrane viability and induced a small and transient genotoxicity, only at the highest concentration tested (40 mg/mL). In a rat wound model, CMC at 10 mg/mL associated with ADSCs increased the rate of cell proliferation of the granulation tissue and epithelium thickness when compared to untreated lesions (Sham), but did not increase collagen fibers nor alter the overall speed of wound closure. Taken together, the results show that the CMC is capable to allow the growth of ADSCs and is safe for this biological application up to the concentration of 20 mg/mL."

According to the news editors, the research concluded: "These findings suggest that CMC is a promising biomaterial to be used in cell therapy."

For more information on this research see: New therapy of skin repair combining adipose-derived mesenchymal stem cells with sodium carboxymethylcellulose scaffold in a pre-clinical rat model. Plos One, 2014;9(5):e96241. (Public Library of Science - www.plos.org; Plos One - www.plosone.org)

The news editors report that additional information may be obtained by contacting C. Rodrigues, Laboratorios de Pesquisa em Biologia Celular, Departamento de Ciencias Basicas da Saude, Universidade Federal de Ciencias da Saude de Porto Alegre, Porto Alegre, RS, Brazil. Additional authors for this research include A.M. de Assis, D.J. Moura, G. Halmenschlager, J. Saffi, L.L. Xavier, M.DAC. Fernandes and M.R Wink (see also Stem Cell Research).

Keywords for this news article include: Tissue Engineering, Biomedical Engineering, Biomedicine, Brazil, Therapy, Porto Alegre, South America, Bioengineering, Stem Cell Research, Mesenchymal Stem Cells.

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Biotech Week


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