Reports Summarize Anions Findings from University of Duisburg-Essen (Targeting and activation of antigen-specific B-cells by calcium phosphate nanoparticles loaded with protein antigen)
By a News Reporter-Staff News Editor at Life Science Weekly -- Investigators publish new report on Anions. According to news reporting out of Essen, Germany, by NewsRx editors, research stated, "Cross-linking of the B-cell receptors of an antigen-specific B-cell is the initial signal for B-cell activation, proliferation, and differentiation into antibody secreting plasma cells. Since multivalent particulate structures are efficient activators of antigen-specific B-cells, we developed biodegradable calcium phosphate nanoparticles displaying protein antigens on their surface and explored the efficacy of the B-cell activation after exposure to these nanoparticles."
Our news journalists obtained a quote from the research from the University of Duisburg-Essen, "The calcium phosphate nanoparticles were functionalized with the model antigen Hen Egg Lysozyme (HEL) to take advantage of a HEL-specific B-cell receptor transgenic mouse model. The nanoparticles were characterized by scanning electron microscopy and dynamic light scattering. The functionalized calcium phosphate nanoparticles were preferentially bound and internalized by HEL-specific B-cells. Co-cultivation of HEL-specific B-cells with the functionalized nanoparticles also increased surface expression of B-cell activation markers. Functionalized nanoparticles were able to effectively cross-link B-cell receptors at the surface of antigen-matched B-cells and were 100-fold more efficient in the activation of B-cells than soluble HEL."
According to the news editors, the research concluded: "Thus, calcium phosphate nanoparticles coated with protein antigens are promising vaccine candidates for induction humoral immunity."
For more information on this research see: Targeting and activation of antigen-specific B-cells by calcium phosphate nanoparticles loaded with protein antigen. Biomaterials, 2014;35(23):6098-6105. Biomaterials can be contacted at: Elsevier Sci Ltd, The Boulevard, Langford Lane, Kidlington, Oxford OX5 1GB, Oxon, England. (Elsevier - www.elsevier.com; Biomaterials - www.elsevier.com/wps/product/cws_home/30392)
Our news journalists report that additional information may be obtained by contacting V.V. Temchura, University of Duisburg Essen, Inorgan Chem & Center Nanointegrat Duisburg Essen Ce, D-45117 Essen, Germany. Additional authors for this research include D. Kozlova, V. Sokolova, K. Uberla and M. Epple (see also Anions).
Keywords for this news article include: Essen, Europe, Anions, Germany, Nanoparticle, Nanotechnology, Phosphoric Acids, Calcium Compounds, Calcium Phosphates, Inorganic Chemicals, Phosphorus Compounds, Emerging Technologies
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