Reports Outline Griseofulvin Therapy Findings from University of Southern Denmark (Solid phospholipid nano-particles: investigations into formulation and dissolution properties of griseofulvin)
By a News Reporter-Staff News Editor at Biotech Week -- A new study on Drugs and Therapies is now available. According to news reporting out of Odense, Denmark, by NewsRx editors, research stated, "Solid phospholipid (PL) nanoparticles with griseofulvin (GRIS) as a model drug were prepared by co-spray drying. Their dissolution properties were compared with formulations containing the physical blends of the native crystalline drug and excipient materials, and physical blends of the spray dried materials."
Our news journalists obtained a quote from the research from the University of Southern Denmark, "Co-spray drying was performed from ethanol+water solutions (80+20) using Buchi Nano Spray Dryer B-90. Dissolution profiles in phosphate buffer (PBS), simulated intestinal fluids (fasted state simulated intestinal fluid (FaSSIF)) and pancreatin containing media (PAN) were studied. It was found that the influence of PL on the dissolution profile was affected by both the solid state of the drug formulation and the dissolution medium: the co-SD formulations showed the fastest release in all media. The amount of GRIS dissolved after 5h increases by a factor of 7 for the co SD as compared to physical blend of native materials in PBS, and a factor of 4 in FaSSIF respectively. Surprisingly, in contrast to PBS, dissolution rate in FaSSIF decreased with increasing the PL content."
According to the news editors, the research concluded: "All the pancreatin containing media showed a decrease in dissolution rate and extent independently of the processing methods due to an incompatibility between GRIS and PAN."
For more information on this research see: Solid phospholipid nano-particles: investigations into formulation and dissolution properties of griseofulvin. International Journal of Pharmaceutics, 2014;467(1-2):42-7. (Elsevier - www.elsevier.com; International Journal of Pharmaceutics - www.elsevier.com/wps/product/cws_home/505513)
Our news journalists report that additional information may be obtained by contacting U. Brinkmann-Trettenes, Dept. of Physics, Chemistry and Pharmacy, University of Southern Denmark, Campusvej 55, 5230 Odense M, Denmark (see also Drugs and Therapies).
Keywords for this news article include: Antifungals, Antiinfectives, Pharmaceuticals, Odense, Europe, Denmark, Griseofulvin, Drugs and Therapies.
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