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Reports Outline Breast Cancer Findings from Weill Cornell Medical College (Targeting RPL39 and MLF2 reduces tumor initiation and metastasis in breast...

July 15, 2014



Reports Outline Breast Cancer Findings from Weill Cornell Medical College (Targeting RPL39 and MLF2 reduces tumor initiation and metastasis in breast cancer by inhibiting nitric oxide synthase signaling)

By a News Reporter-Staff News Editor at Cancer Weekly -- New research on Oncology is the subject of a report. According to news reporting from New York City, New York, by NewsRx journalists, research stated, "We previously described a gene signature for breast cancer stem cells (BCSCs) derived from patient biopsies. Selective shRNA knockdown identified ribosomal protein L39 (RPL39) and myeloid leukemia factor 2 (MLF2) as the top candidates that affect BCSC self-renewal."

The news correspondents obtained a quote from the research from Weill Cornell Medical College, "Knockdown of RPL39 and MLF2 by specific siRNA nanoparticles in patient-derived and human cancer xenografts reduced tumor volume and lung metastases with a concomitant decrease in BCSCs. RNA deep sequencing identified damaging mutations in both genes. These mutations were confirmed in patient lung metastases (n = 53) and were statistically associated with shorter median time to pulmonary metastasis. Both genes affect the nitric oxide synthase pathway and are altered by hypoxia."

According to the news reporters, the research concluded: "These findings support that extensive tumor heterogeneity exists within primary cancers; distinct subpopulations associated with stem-like properties have increased metastatic potential."

For more information on this research see: Targeting RPL39 and MLF2 reduces tumor initiation and metastasis in breast cancer by inhibiting nitric oxide synthase signaling. Proceedings of the National Academy of Sciences of the United States of America, 2014;111(24):8838-8843. Proceedings of the National Academy of Sciences of the United States of America can be contacted at: Natl Acad Sciences, 2101 Constitution Ave NW, Washington, DC 20418, USA. (National Academy of Sciences - www.nasonline.org/; Proceedings of the National Academy of Sciences of the United States of America - www.nasonline.org/publications/pnas/)

Our news journalists report that additional information may be obtained by contacting B. Dave, Weill Cornell Med College, New York, NY 10065, United States. Additional authors for this research include S. Granados-Principal, R. Zhu, S. Benz, S. Rabizadeh, P. Soon-Shiong, K.D. Yu, Z.M. Shao, X.X. Li, M. Gilcrease, Z. Lai, Y.D. Cheng, T.H.M. Huang, H.F. Shen, X.W. Liu, M. Ferrari, M. Zhan, S.T.C. Wong, M. Kumaraswami and Mittal (see also Oncology).

Keywords for this news article include: Genetics, Oncology, Chemicals, Chemistry, New York City, United States, Breast Cancer, Women's Health, Nitrogen Oxides, Enzymes and Coenzymes, Nitric Oxide Synthase, North and Central America, Reactive Nitrogen Species, Amino Acid Oxidoreductases

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Cancer Weekly


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