Reports from University of Tokyo Add New Data to Findings in Bone Research [The Use of Bone Marrow Stromal Cells (Bone Marrow-Derived Multipotent Mesenchymal Stromal Cells) for Alveolar Bone Tissue Engineering: Basic Science to Clinical ...]
By a News Reporter-Staff News Editor at Biotech Week -- Investigators discuss new findings in Bone Research. According to news originating from Tokyo, Japan, by NewsRx correspondents, research stated, "Bone tissue engineering is a promising field of regenerative medicine in which cultured cells, scaffolds, and osteogenic inductive signals are used to regenerate bone. Human bone marrow stromal cells (BMSCs) are the most commonly used cell source for bone tissue engineering."
Our news journalists obtained a quote from the research from the University of Tokyo, "Although it is known that cell culture and induction protocols significantly affect the in vivo bone forming ability of BMSCs, the responsible factors of clinical outcome are poorly understood. The results from recent studies using human BMSCs have shown that factors such as passage number and length of osteogenic induction significantly affect ectopic bone formation, although such differences hardly affected the alkaline phosphatase activity or gene expression of osteogenic markers. Application of basic fibroblast growth factor helped to maintain the in vivo osteogenic ability of BMSCs. Importantly, responsiveness of those factors should be tested under clinical circumstances to improve the bone tissue engineering further."
According to the news editors, the research concluded: "In this review, clinical application of bone tissue engineering was reviewed with putative underlying mechanisms."
For more information on this research see: The Use of Bone Marrow Stromal Cells (Bone Marrow-Derived Multipotent Mesenchymal Stromal Cells) for Alveolar Bone Tissue Engineering: Basic Science to Clinical Translation. Tissue Engineering Part B-Reviews, 2014;20(3):229-232. Tissue Engineering Part B-Reviews can be contacted at: Mary Ann Liebert, Inc, 140 Huguenot Street, 3RD Fl, New Rochelle, NY 10801, USA (see also Bone Research).
The news correspondents report that additional information may be obtained from H. Kagami, University of Tokyo, Inst Med Sci, IMSUT Hosp, Center Antibody & Vaccine, Tokyo 1088639, Japan. Additional authors for this research include H. Agata, M. Inoue, I. Asahina, A. Tojo, N. Yamashita and K. Imai.
Keywords for this news article include: Asia, Tokyo, Japan, Bone Marrow, Bone Research, Immune System, Stromal Cells, Connective Tissue Cells
Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC