Reports from University of Coimbra Advance Knowledge in Squamous Cell Carcinoma (Genetic imbalances detected by multiplex ligation-dependent probe amplification in a cohort of patients with oral squamous cell carcinoma-the first step towards ...)
By a News Reporter-Staff News Editor at Genomics & Genetics Weekly -- Fresh data on Oncology are presented in a new report. According to news reporting out of Coimbra, Portugal, by NewsRx editors, research stated, "Oral tumors are a growing health problem worldwide; thus, it is mandatory to establish genetic markers in order to improve diagnosis and early detection of tumors, control relapses and, ultimately, delineate individualized therapies. This study was the first to evaluate and discuss the clinical applicability of a multiplex ligation-dependent probe amplification (MLPA) probe panel directed to head and neck cancer."
Our news journalists obtained a quote from the research from the University of Coimbra, "Thirty primary oral squamous cell tumors were analyzed using the P428 MLPA probe panel. We detected genetic imbalances in 26 patients and observed a consistent pattern of distribution of genetic alterations in terms of losses and gains for some chromosomes, particularly for chromosomes 3, 8, and 11. Regarding the latter, some specific genes were highlighted due to frequent losses of genetic material--RARB, FHIT, CSMD1, GATA4, and MTUS1--and others due to gains--MCCC1, MYC, WISP1, PTK2, CCND1, FGF4, FADD, and CTTN. We also verified that the gains of MYC and WISP1 genes seem to suggest higher propensity of tumors localized in the floor of the mouth. This study proved the value of this MLPA probe panel for a first-tier analysis of oral tumors. The probemix was developed to include target regions that have been already shown to be of diagnostic/prognostic relevance for oral tumors."
According to the news editors, the research concluded: "Furthermore, this study emphasized several of those specific genetic targets, suggesting its importance to oral tumor development, to predict patients' outcomes, and also to guide the development of novel molecular therapies."
For more information on this research see: Genetic imbalances detected by multiplex ligation-dependent probe amplification in a cohort of patients with oral squamous cell carcinoma-the first step towards clinical personalized medicine. Tumor Biology, 2014;35(5):4687-95. (Springer - www.springer.com; Tumor Biology - www.springerlink.com/content/1010-4283/)
Our news journalists report that additional information may be obtained by contacting I.P. Ribeiro, Cytogenetics and Genomics Laboratory, Faculty of Medicine, University of Coimbra, 3000-354, Coimbra, Portugal. Additional authors for this research include F. Marques, F. Caramelo, J. Ferrao, H. Prazeres, M.J. Juliao, W. Rifi, S. Savola, J.B. de Melo, I.P. Baptista and I.M Carreira (see also Oncology).
Keywords for this news article include: Europe, Coimbra, Portugal, Genetics, Oncology, Squamous Cell Carcinoma.
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