Reports from Georgetown University Highlight Recent Findings in Nanotechnology (Magnetic nanobeads as potential contrast agents for magnetic resonance imaging)
By a News Reporter-Staff News Editor at Health & Medicine Week -- Investigators discuss new findings in Nanotechnology. According to news reporting originating in Washington, District of Columbia, by NewsRx journalists, research stated, "Metal-oxo clusters have been used as building blocks to form hybrid nanomaterials and evaluated as potential MRI contrast agents. We have synthesized a biocompatible copolymer based on a water stable, nontoxic, mixed-metal-oxo cluster, Mn8Fe4O12(L)16(H2O)4, where L is acetate or vinyl benzoic acid, and styrene."
The news reporters obtained a quote from the research from Georgetown University, "The cluster alone was screened by NMR for relaxivity and was found to be a promising T2 contrast agent, with r1=2.3 mM(-1) s(-1) and r2=29.5 mM(-1) s(-1). Initial cell studies on two human prostate cancer cell lines, DU-145 and LNCap, reveal that the cluster has low cytotoxicity and may be potentially used in vivo. The metal-oxo cluster Mn8Fe4(VBA)16 (VBA=vinyl benzoic acid) can be copolymerized with styrene under miniemulsion conditions. Miniemulsion allows for the formation of nanometer-sized paramagnetic beads (~80 nm diameter), which were also evaluated as a contrast agent for MRI. These highly monodispersed, hybrid nanoparticles have enhanced properties, with the option for surface functionalization, making them a promising tool for biomedicine."
According to the news reporters, the research concluded: "Interestingly, both relaxivity measurements and MRI studies show that embedding the Mn8Fe4 core within a polymer matrix decreases r2 effects with little effect on r1, resulting in a positive T1 contrast enhancement."
For more information on this research see: Magnetic nanobeads as potential contrast agents for magnetic resonance imaging. Acs Nano, 2013;7(10):9040-8. (American Chemical Society - www.acs.org; Acs Nano - www.pubs.acs.org/journal/ancac3)
Our news correspondents report that additional information may be obtained by contacting M.H. Pablico-Lansigan, Dept. of Chemistry, Georgetown University , 37th and O Streets NW, Washington, DC 20057, United States. Additional authors for this research include W.J. Hickling, E.A. Japp, O.C. Rodriguez, A. Ghosh, C. Albanese, M. Nishida, E. Van Keuren, S. Fricke, N. Dollahon and S.L Stoll (see also Nanotechnology).
Keywords for this news article include: Washington, United States, Nanotechnology, District of Columbia, North and Central America.
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