Reports from Chinese People's Liberation Army General Hospital Add New Data to Findings in Methicillin-Resistant Staphylococcus aureus (Susceptibility of methicillin-resistant Staphylococcus aureus to photodynamic antimicrobial chemotherapy ...)
By a News Reporter-Staff News Editor at Biotech Week -- Research findings on MRSA are discussed in a new report. According to news reporting from Beijing, People's Republic of China, by NewsRx journalists, research stated, "The incidence of methicillin-resistant strains of Staphylococcus aureus (MRSA) is increasing globally, making urgent the discovery of novel alternative therapies for infections. Photodynamic antimicrobial chemotherapy (PACT), based on oxidative damage to subcellular structures, has the advantage of circumventing multidrug resistance, and is becoming a potential therapeutic modality for methicillin-resistant bacteria."
The news correspondents obtained a quote from the research from Chinese People's Liberation Army General Hospital, "The key to PACT is photosensitization. This study demonstrates the efficiency of PACT using alpha-d-galactopyranosyl zinc phthalocyanines (T1-T4) for the photosensitization of MRSA, Escherichia coli, and Pseudomonas aeruginosa. Bacterial suspensions were illuminated with 650-nm light from a semiconductor laser at 0.2 W/cm(2), and the energy density was maintained at 6 J/cm(2) in the presence of different concentrations of photosensitizer. The treatment response was evaluated based on the numbers of bacterial colony-forming units. PACT with these phthalocyanines strongly affected MRSA, but weakly affected E. coli and P. aeruginosa. The efficiency of PACT on MRSA with these four phthalocyanine compounds decreased in the order T1 > T2 > T3 > T4. T1-PACT eliminated > 99 % of MRSA in a concentration range of 25-50 mu M and at an energy density of 6 J/cm(2). Uptake measurements revealed that the PACT effect correlated with the bacterial uptake of the photosensitizer and that 4-30-fold more T1 than T2-T4 was taken up by the MRSA strain, which was confirmed with laser confocal microscopy."
According to the news reporters, the research concluded: "These data suggest that T1 is an efficient PACT photosensitizer for MRSA."
For more information on this research see: Susceptibility of methicillin-resistant Staphylococcus aureus to photodynamic antimicrobial chemotherapy with alpha-D-galactopyranosyl zinc phthalocyanines: in vitro study. Lasers in Medical Science, 2014;29(3):1131-1138. Lasers in Medical Science can be contacted at: Springer London Ltd, 236 Grays Inn Rd, 6TH Floor, London WC1X 8HL, England. (Springer - www.springer.com; Lasers in Medical Science - www.springerlink.com/content/0268-8921/)
Our news journalists report that additional information may be obtained by contacting Z.J. Zhao, Chinese Peoples Liberat Army Gen Hosp, Affiliated Hosp 304 1, Beijing 100037, People's Republic of China. Additional authors for this research include Y.Z. Li, S. Meng, S.Z. Li, Q. Wang and T.J. Liu (see also MRSA).
Keywords for this news article include: Asia, MRSA, Antimicrobial Resistance, Biotechnology, Amides, Beijing, Bacillales, Chemotherapy, Photodynamics, Drug Resistance, Organic Chemicals, Staphylococcaceae, Gram-Positive Cocci, Penicillin Resistance, Gram-Positive Bacteria, Methicillin Resistance, beta-Lactam Resistance, Beta-Lactam Antibiotics
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