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Reports from A. Mehdizadeh and Co-Researchers Add New Data to Findings in Epidermal Cancer (The effects of folate-conjugated gold nanorods in...

July 15, 2014



Reports from A. Mehdizadeh and Co-Researchers Add New Data to Findings in Epidermal Cancer (The effects of folate-conjugated gold nanorods in combination with plasmonic photothermal therapy on mouth epidermal carcinoma cells)

By a News Reporter-Staff News Editor at Cancer Weekly -- Investigators publish new report on Oncology. According to news reporting originating in Berlin, Germany, by NewsRx journalists, research stated, "The use of lasers has emerged to be highly promising for cancer therapy modalities, most commonly, the photothermal therapy method. Unfortunately, the most common disadvantage of laser therapy is its nonselectivity and requirement of high power density."

The news reporters obtained a quote from the research, "The use of plasmonic nanoparticles as highly enhanced photoabsorbing agents has thus introduced a much more selective and efficient cancer therapy strategy. In this study, we aimed to demonstrate the selective targeting and destruction of mouth epidermal carcinoma cells (KB cells) using the photothermal therapy of folate-conjugated gold nanorods (F-GNRs). Considering the beneficial characteristics of GNRs and overexpression of the folate receptor by KB cells, we selected F-GNRs as a targeted photothermal therapy agent. Cell viability was evaluated using a 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide assay. Apoptosis was determined by flow cytometry using an annexin V-fluorescein isothiocyanate/propidium iodide apoptosis detection kit. No cell damage or cytotoxicity from the individual treatment of laser light or F-GNRs was observed. However, a 56 % cell lethality was achieved for KB cells using combined plasmonic photothermal therapy of 20 mu M F-GNRs with seven pulses of laser light and 6-h incubation periods. Cell lethality strongly depends on the concentration of F-GNRs and the incubation period that is mainly due to the induction of apoptosis. This targeted damage is due to the F-GNRs present in the cancer cells strongly absorbing near-infrared laser light and rapidly converting it to heat."

According to the news reporters, the research concluded: "This new therapeutic avenue for cancer therapy merits further investigation using in vivo models for application in humans."

For more information on this research see: The effects of folate-conjugated gold nanorods in combination with plasmonic photothermal therapy on mouth epidermal carcinoma cells. Lasers in Medical Science, 2014;29(3):939-948. Lasers in Medical Science can be contacted at: Springer London Ltd, 236 Grays Inn Rd, 6TH Floor, London WC1X 8HL, England. (Springer - www.springer.com; Lasers in Medical Science - www.springerlink.com/content/0268-8921/)

Our news correspondents report that additional information may be obtained by contacting A. Mehdizadeh, PlasmaChem GmbH, Dept. of Res & Dev R&D, D-12489 Berlin, Germany. Additional authors for this research include S. Pandesh, A. Shakeri-Zadeh, S.K. Kamrava, M. Habib-Agahi, M. Farhadi, M. Pishghadam, A. Ahmadi, S. Arami and Y. Fedutik (see also Oncology).

Keywords for this news article include: Berlin, Europe, Cancer, Germany, Therapy, KB Cells, Oncology, Apoptosis, Cell Line, Hela Cells, Epidermal Carcinoma

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Cancer Weekly


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