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New Stem Cells Findings from Southwest Jiaotong University Reported (Study of bilineage differentiation of human-bone-marrow-derived mesenchymal stem...

July 16, 2014



New Stem Cells Findings from Southwest Jiaotong University Reported (Study of bilineage differentiation of human-bone-marrow-derived mesenchymal stem cells in oxidized sodium alginate/N-succinyl chitosan hydrogels and synergistic effects of RGD ...)

By a News Reporter-Staff News Editor at Biotech Week -- Researchers detail new data in Stem Cell Research. According to news reporting originating in Chengdu, People's Republic of China, by NewsRx journalists, research stated, "The level of formation of new bone and vascularization in bone tissue engineering scaffold implants is considered as a critical factor for clinical application. In this study, an approach using an RGD-grafted oxidized sodium alginate/N-succinyl chitosan (RGD-OSA/NSC) hydrogel as a scaffold and low-intensity pulsed ultrasound (LIPUS) as mechanical stimulation was proposed to achieve a high level of formation of new bone and vascularization."

The news reporters obtained a quote from the research from Southwest Jiaotong University, "An in vitro study of endothelial and osteogenic differentiations of human-bone-marrow-derived mesenchymal stem cells (hMSCs) was conducted to evaluate it. The results showed that RGD-OSA/NSC composite hydrogels presented good biological properties in attachment, proliferation and differentiation of cells. The MTT cell viability assay showed that the total number of cells increased more significantly in the LIPUS-stimulated groups with RGD than that in the control ones; similar results were obtained for alkaline phosphatase activity/staining and mineralized nodule formation assay of osteogenic induction and immunohistochemical test of endothelial induction. The positive synergistic effect of LIPUS and RGD on the enhancement of proliferation and differentiation of hMSCs was observed."

According to the news reporters, the research concluded: "These findings suggest that the hybrid use of RGD modification and LIPUS might provide one approach to achieve a high level of formation of new bone and vascularization in bone tissue engineering scaffold implants."

For more information on this research see: Study of bilineage differentiation of human-bone-marrow-derived mesenchymal stem cells in oxidized sodium alginate/N-succinyl chitosan hydrogels and synergistic effects of RGD modification and low-intensity pulsed ultrasound. Acta Biomaterialia, 2014;10(6):2518-28. (Elsevier - www.elsevier.com; Acta Biomaterialia - www.elsevier.com/wps/product/cws_home/702994)

Our news correspondents report that additional information may be obtained by contacting Y. Wang, Key Laboratory of Advanced Technologies of Materials, Ministry of Education, School of Materials Science and Engineering, Southwest Jiaotong University, Chengdu 610031, People's Republic of China. Additional authors for this research include W. Peng, X. Liu, M. Zhu, T. Sun, Q. Peng, Y. Zeng, B. Feng, W. Zhi, J. Weng and J. Wang (see also Stem Cell Research).

Keywords for this news article include: Asia, Tissue Engineering, Biomedical Engineering, Biomedicine, Chengdu, Bone Marrow, Bone Research, Immune System, Bioengineering, Stem Cell Research, Mesenchymal Stem Cells, People's Republic of China.

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Biotech Week


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