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New Peptides and Proteins Study Findings Recently Were Reported by Researchers at Kyoto University [Exclusive photothermal heat generation by a...

July 16, 2014



New Peptides and Proteins Study Findings Recently Were Reported by Researchers at Kyoto University [Exclusive photothermal heat generation by a gadolinium bis(naphthalocyanine) complex and inclusion into modified high-density lipoprotein ...]

By a News Reporter-Staff News Editor at Biotech Week -- Data detailed on Proteins have been presented. According to news reporting originating from Kyoto, Japan, by NewsRx correspondents, research stated, "A hydrophobic gadolinium bis(naphthalocyanine) sandwich complex (GdSand) possessing several absorbances across visible and infrared wavelengths (up to 2500 nm) was solubilized in aqueous solution by uptake into a nascent mutant high-density lipoprotein (HDL) nanocarrier. The HDL nanocarrier was additionally functionalized with a trans-activator of transcription peptide sequence to promote efficient cell penetration of the drug delivery system (cpHDL)."

Our news editors obtained a quote from the research from Kyoto University, "The dye-loaded nanocarrier (GdSand@cpHDL) exhibited photothermal heat generation properties upon irradiation with near-infrared (NIR) laser light, with controllable heat generation abilities as a function of the incident laser light power. Comparison of the photothermal behavior of the dyes GdSand and the well-explored molecular photothermal agent indocyanine green (ICG) in the cpHDL nanocarrier (i.e., ICG@cpHDL) revealed two significant advantages of GdSand@cpHDL: (1) the ability to maintain elevated temperatures upon light absorption for extended periods of time, with a reduced degree of self-destruction of the dye, and (2) exclusive photothermal heat generation with no detectable singlet oxygen production leading to improved integrity of the cpHDL nanocarrier after irradiation."

According to the news editors, the research concluded: "Finally, GdSand@cpHDL was successfully subjected to an in vitro study against NCI-H460 human lung cancer cells, demonstrating the proof-of-principle utility of lanthanide sandwich complexes in photothermal therapeutic applications."

For more information on this research see: Exclusive photothermal heat generation by a gadolinium bis(naphthalocyanine) complex and inclusion into modified high-density lipoprotein nanocarriers for therapeutic applications. Acs Nano, 2013;7(10):8908-16. (American Chemical Society - www.acs.org; Acs Nano - www.pubs.acs.org/journal/ancac3)

The news editors report that additional information may be obtained by contacting S. Mathew, Institute for Integrated Cell-Material Sciences (WPI-iCeMS), Kyoto University , Sakyo-ku, Kyoto 606-8501, Japan. Additional authors for this research include T. Murakami, H. Nakatsuji, H. Okamoto, N. Morone, J.E. Heuser, M. Hashida and H. Imahori (see also Proteins).

Keywords for this news article include: Asia, Kyoto, Japan, Lipids, Gadolinium, Lipoproteins, Nanocarriers, Therapeutics, Nanotechnology, Emerging Technologies, Lanthanoid Series Elements.

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Biotech Week


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