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New Medicinal Chemistry Findings from Netaji Subhas Institute of Technology Outlined (Antitrypanosomal activity & docking studies of components...

July 18, 2014



New Medicinal Chemistry Findings from Netaji Subhas Institute of Technology Outlined (Antitrypanosomal activity & docking studies of components of Crateva adansonii DC leaves: novel multifunctional scaffolds)

By a News Reporter-Staff News Editor at Health & Medicine Week -- New research on Health and Medicine is the subject of a report. According to news reporting out of New Delhi, India, by NewsRx editors, research stated, "Chemical investigation of Crateva adansonii DC has led to the isolation of aurantiamide acetate, a novel ethyl pyropheophorbide A, purpurin-18 ethyl ester and pyropheophorbide A. Their structures were elucidated using extensive spectral data."

Our news journalists obtained a quote from the research from the Netaji Subhas Institute of Technology, "These metabolites were then evaluated for their in vitro bioactivity against the African trypanosome Trypanosoma brucei brucei (S427) blood stream forms. Anti-trypanosomal activity decreased with aurantiamide acetate (MIC 25M), while it increased with the pheopytins (MIC 6.25M), when compared to the standard drug Suramin. Using the Vlife MDS 4.3 -GRIP docking, these phytoconstituents were then tested to identify the proteins targeted and the mode of activity employed."

According to the news editors, the research concluded: "Their affinity towards the receptor sites of trypanothione reductase, riboflavin kinase, rohedsain, glutathione synthetase & sterol-14?-demethylase (CYP51) of Trypanosoma brucei were evaluated according to the resulting docking energies."

For more information on this research see: Antitrypanosomal activity & docking studies of components of Crateva adansonii DC leaves: novel multifunctional scaffolds. Current Topics In Medicinal Chemistry, 2014;14(8):981-90. (Bentham Science Publishers - www.benthamscience.com; Current Topics In Medicinal Chemistry - www.benthamscience.com/ctmc/index.htm)

Our news journalists report that additional information may be obtained by contacting N.P. Igoli, Division of Biotechnology, Netaji Subhas Institute of Technology, Azad Hind Fauz Marg, Sector-3, Dwarka-110078, New Delhi, India. Additional authors for this research include C.J. Clements, R.K. Singla, J.O. Igoli, N. Uche and A.I Gray (see also Health and Medicine).

Keywords for this news article include: Asia, India, New Delhi, Health and Medicine.

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Health & Medicine Week


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