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New General Chemistry Findings from University of Belgrade Discussed [Organotin(IV)-Loaded Mesoporous Silica as a Biocompatible Strategy in Cancer...

July 15, 2014

New General Chemistry Findings from University of Belgrade Discussed [Organotin(IV)-Loaded Mesoporous Silica as a Biocompatible Strategy in Cancer Treatment]

By a News Reporter-Staff News Editor at Cancer Weekly -- Investigators publish new report on General Chemistry. According to news reporting originating in Belgrade, Serbia, by NewsRx journalists, research stated, "The strong therapeutic potential of an organotin(IV) compound loaded in nanostructured silica (SBA-15pSn) is demonstrated: B16 melanoma tumor growth in syngeneic C57BL/6 mice is almost completely abolished."

The news reporters obtained a quote from the research from the University of Belgrade, "In contrast to apoptosis as the basic mechanism of the anticancer action of numerous chemotherapeutics, the important advantage of this SBA-15pSn mesoporous material is the induction of cell differentiation, an effect unknown for metal-based drugs and nanomaterials alone. This non-aggressive mode of drug action is highly efficient against cancer cells but is in the concentration range used nontoxic for normal tissue."

According to the news reporters, the research concluded: "JNK (Jun-amino-terminal kinase)-independent apoptosis accompanied by the development of the melanocyte-like nonproliferative phenotype of survived cells indicates the extraordinary potential of SBA-15pSn to suppress tumor growth without undesirable compensatory proliferation of malignant cells in response to neighboring cell death."

For more information on this research see: Organotin(IV)-Loaded Mesoporous Silica as a Biocompatible Strategy in Cancer Treatment. Angewandte Chemie-International Edition, 2014;53(23):5982-5987. Angewandte Chemie-International Edition can be contacted at: Wiley-V C H Verlag Gmbh, Boschstrasse 12, D-69469 Weinheim, Germany (see also General Chemistry).

Our news correspondents report that additional information may be obtained by contacting M.Z. Bulatovic, University of Belgrade, Fac Biol, Center Electron Microscopy, Belgrade 11000, Serbia. Additional authors for this research include D. Maksimovic-Ivanic, C. Bensing, S. Gomez-Ruiz, D. Steinborn, H. Schmidt, M. Mojic, A. Korac, I. Golic, D. Perez-Quintanilla, M. Momcilovic, S. Mijatovic and G.N. Kaluderovic.

Keywords for this news article include: Serbia, Europe, Cancer, Belgrade, Oncology, General Chemistry

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Source: Cancer Weekly

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