New Gene Therapy Study Findings Recently Were Reported by Researchers at Zhejiang University (TAT conjugated cationic noble metal nanoparticles for gene delivery to epidermal stem cells)
By a News Reporter-Staff News Editor at Gene Therapy Weekly -- Investigators discuss new findings in Biotechnology. According to news reporting originating from Hangzhou, People's Republic of China, by NewsRx correspondents, research stated, "Most nonviral gene delivery systems are not efficient enough to manipulate the difficult-to-transfect cell types, including non-dividing, primary, neuronal or stem cells, due to a lack of an intrinsic capacity to enter the membrane and nucleus, release its DNA payload, and activate transcription. Noble metal nanoclusters have emerged as a fascinating area of widespread interest in nanomaterials."
Our news editors obtained a quote from the research from Zhejiang University, "Herein, we report the synthesis of the TAT peptide conjugated cationic noble metal nanoparticles (metal NPs@PEI-TAT) as highly efficient carriers for gene delivery to stem cells. The metal NPs@PEI-TAT integrate the advantages of metal NPs and peptides: the presence of metal NPs can effectively decrease the cytotoxicity of cationic molecules, making it possible to apply them in biological systems, while the cell penetrating peptides are essential for enhanced cellular and nucleus entry to achieve high transfection efficiency."
According to the news editors, the research concluded: "Our studies provide strong evidence that the metal NPs@PEI-TAT can be engineered as gene delivery agents for stem cells and subsequently enhance their directed differentiation for biomedical application."
For more information on this research see: TAT conjugated cationic noble metal nanoparticles for gene delivery to epidermal stem cells. Biomaterials, 2014;35(21):5605-18. (Elsevier - www.elsevier.com; Biomaterials - www.elsevier.com/wps/product/cws_home/30392)
The news editors report that additional information may be obtained by contacting L.H. Peng, Institute of Pharmaceutics, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou 310058, People's Republic of China. Additional authors for this research include J. Niu, C.Z. Zhang, W. Yu, J.H. Wu, Y.H. Shan, X.R. Wang, Y.Q. Shen, Z.W. Mao, W.Q. Liang and J.Q Gao (see also Biotechnology).
Keywords for this news article include: Asia, Biotechnology, Hangzhou, Gene Therapy, Bioengineering, Nanotechnology, Stem Cell Research, Metal Nanoparticles, Emerging Technologies, People's Republic of China.
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