New Findings Reported from Institute for Food Research Describe Advances in Vaccines (Immune responses to vaccines involving a combined antigen-nanoparticle mixture and nanoparticle-encapsulated antigen formulation)
By a News Reporter-Staff News Editor at Vaccine Weekly -- Fresh data on Immunization are presented in a new report. According to news reporting from Beijing, People's Republic of China, by NewsRx journalists, research stated, "Many physicochemical characteristics significantly influence the adjuvant effect of micro/nanoparticles; one critical factor is the kinetics of antigen exposure to the immune system by particle-adjuvanted vaccines. Here, we investigated how various antigen-nanoparticle formulations impacted antigen exposure to the immune system and the resultant antigen-specific immune responses."
The news correspondents obtained a quote from the research from Institute for Food Research, "We formulated antigen with poly(lactic-co-glycolic acid) (PLGA) nanoparticles by encapsulating antigen within nanoparticles or by simply mixing soluble antigen with the nanoparticles. Our results indicated that the combined formulation (composed of antigen encapsulated in nanoparticles and antigen mixed with nanoparticles) induced more powerful antigen-specific immune responses than each single-component formulation. Mice immunized with the combined vaccine formulation displayed enhanced induction of antigen-specific IgG antibodies with high avidity, increased cytokine secretion by splenocytes, and improved generation of memory T cell. Enhanced immune responses elicited by the combined vaccine formulation might be attributed to the antigen-depot effect at the injection site, effective provision of both adequate initial antigen exposure and long-term antigen persistence, and efficient induction of dendritic cell (DC) activation and follicular helper T cell differentiation in draining lymph nodes."
According to the news reporters, the research concluded: "Understanding the effect of antigen nanoparticle formulations on the resultant immune responses might have significant implications for rational vaccine design."
For more information on this research see: Immune responses to vaccines involving a combined antigen-nanoparticle mixture and nanoparticle-encapsulated antigen formulation. Biomaterials, 2014;35(23):6086-6097. Biomaterials can be contacted at: Elsevier Sci Ltd, The Boulevard, Langford Lane, Kidlington, Oxford OX5 1GB, Oxon, England. (Elsevier - www.elsevier.com; Biomaterials - www.elsevier.com/wps/product/cws_home/30392)
Our news journalists report that additional information may be obtained by contacting W.F. Zhang, Natl Inst Food & Drug Control, Beijing 100050, People's Republic of China. Additional authors for this research include L.Y. Wang, Y. Liu, X.M. Chen, Q. Liu, J.L. Jia, T.Y. Yang, S.H. Qiu and G.H. Ma (see also Immunization).
Keywords for this news article include: Asia, Beijing, Vaccines, Immunization, Nanoparticle, Nanotechnology, Biological Products, Emerging Technologies, People's Republic of China
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