News Column

New Findings from V.J. Dercksen and Colleagues Has Provided New Data on Neurons (The Filament Editor: an interactive software environment for...

July 15, 2014



New Findings from V.J. Dercksen and Colleagues Has Provided New Data on Neurons (The Filament Editor: an interactive software environment for visualization, proof-editing and analysis of 3D neuron morphology)

By a News Reporter-Staff News Editor at Life Science Weekly -- Data detailed on Neurons have been presented. According to news reporting from Berlin, Germany, by NewsRx journalists, research stated, "Neuroanatomical analysis, such as classification of cell types, depends on reliable reconstruction of large numbers of complete 3D dendrite and axon morphologies. At present, the majority of neuron reconstructions are obtained from preparations in a single tissue slice in vitro, thus suffering from cut off dendrites and, more dramatically, cut off axons."

The news correspondents obtained a quote from the research, "In general, axons can innervate volumes of several cubic millimeters and may reach path lengths of tens of centimeters. Thus, their complete reconstruction requires in vivo labeling, histological sectioning and imaging of large fields of view. Unfortunately, anisotropic background conditions across such large tissue volumes, as well as faintly labeled thin neurites, result in incomplete or erroneous automated tracings and even lead experts to make annotation errors during manual reconstructions. Consequently, tracing reliability renders the major bottleneck for reconstructing complete 3D neuron morphologies. Here, we present a novel set of tools, integrated into a software environment named 'Filament Editor', for creating reliable neuron tracings from sparsely labeled in vivo datasets. The Filament Editor allows for simultaneous visualization of complex neuronal tracings and image data in a 3D viewer, proof-editing of neuronal tracings, alignment and interconnection across sections, and morphometric analysis in relation to 3D anatomical reference structures."

According to the news reporters, the research concluded: "We illustrate the functionality of the Filament Editor on the example of in vivo labeled axons and demonstrate that for the exemplary dataset the final tracing results after proof-editing are independent of the expertise of the human operator."

For more information on this research see: The Filament Editor: an interactive software environment for visualization, proof-editing and analysis of 3D neuron morphology. Neuroinformatics, 2014;12(2):325-39. Neuroinformatics can be contacted at: Springer, 233 Spring Street, New York, NY 10013, USA. (Springer - www.springer.com; Neuroinformatics - www.springerlink.com/content/1539-2791/)

Our news journalists report that additional information may be obtained by contacting V.J. Dercksen, Dept. of Visualization and Data Analysis, Zuse Institute Berlin, Takustraße 7, 14195, Berlin, Germany. Additional authors for this research include H.C. Hege and M. Oberlaender (see also Neurons).

Publisher contact information for the journal Neuroinformatics is: Springer, 233 Spring Street, New York, NY 10013, USA.

Keywords for this news article include: Cells, Berlin, Europe, Germany, Neurons, Software.

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


For more stories covering the world of technology, please see HispanicBusiness' Tech Channel



Source: Life Science Weekly


Story Tools






HispanicBusiness.com Facebook Linkedin Twitter RSS Feed Email Alerts & Newsletters