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The news correspondents obtained a quote from the research, "In general, axons can innervate volumes of several cubic millimeters and may reach path lengths of tens of centimeters. Thus, their complete reconstruction requires in vivo labeling, histological sectioning and imaging of large fields of view. Unfortunately, anisotropic background conditions across such large tissue volumes, as well as faintly labeled thin neurites, result in incomplete or erroneous automated tracings and even lead experts to make annotation errors during manual reconstructions. Consequently, tracing reliability renders the major bottleneck for reconstructing complete 3D neuron morphologies. Here, we present a novel set of tools, integrated into a software environment named 'Filament Editor', for creating reliable neuron tracings from sparsely labeled in vivo datasets. The Filament Editor allows for simultaneous visualization of complex neuronal tracings and image data in a 3D viewer, proof-editing of neuronal tracings, alignment and interconnection across sections, and morphometric analysis in relation to 3D anatomical reference structures."
According to the news reporters, the research concluded: "We illustrate the functionality of the Filament Editor on the example of in vivo labeled axons and demonstrate that for the exemplary dataset the final tracing results after proof-editing are independent of the expertise of the human operator."
For more information on this research see: The Filament Editor: an interactive software environment for visualization, proof-editing and analysis of 3D neuron morphology. Neuroinformatics, 2014;12(2):325-39. Neuroinformatics can be contacted at: Springer,
Our news journalists report that additional information may be obtained by contacting
Publisher contact information for the journal Neuroinformatics is: Springer,
Keywords for this news article include: Cells,
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