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New Biotechnology Study Findings Recently Were Reported by N.C. Kleinstreuer and Co-Researchers (Phenotypic screening of the ToxCast chemical library...

July 16, 2014



New Biotechnology Study Findings Recently Were Reported by N.C. Kleinstreuer and Co-Researchers (Phenotypic screening of the ToxCast chemical library to classify toxic and therapeutic mechanisms)

By a News Reporter-Staff News Editor at Biotech Week -- Current study results on Technology have been published. According to news reporting originating in San Francisco, California, by NewsRx journalists, research stated, "Addressing the safety aspects of drugs and environmental chemicals has historically been undertaken through animal testing. However, the quantity of chemicals in need of assessment and the challenges of species extrapolation require the development of alternative approaches."

The news reporters obtained a quote from the research, "Our approach, the US Environmental Protection Agency's ToxCast program, utilizes a large suite of in vitro and model organism assays to interrogate important chemical libraries and computationally analyze bioactivity profiles. Here we evaluated one component of the ToxCast program, the use of primary human cell systems, by screening for chemicals that disrupt physiologically important pathways. Chemical-response signatures for 87 endpoints covering molecular functions relevant to toxic and therapeutic pathways were generated in eight cell systems for 641 environmental chemicals and 135 reference pharmaceuticals and failed drugs. Computational clustering of the profiling data provided insights into the polypharmacology and potential off-target effects for many chemicals that have limited or no toxicity information. The endpoints measured can be closely linked to in vivo outcomes, such as the upregulation of tissue factor in endothelial cell systems by compounds linked to the risk of thrombosis in vivo."

According to the news reporters, the research concluded: "Our results demonstrate that assaying complex biological pathways in primary human cells can identify potential chemical targets, toxicological liabilities and mechanisms useful for elucidating adverse outcome pathways."

For more information on this research see: Phenotypic screening of the ToxCast chemical library to classify toxic and therapeutic mechanisms. Nature Biotechnology, 2014;32(6):583-591,123-125. Nature Biotechnology can be contacted at: Nature Publishing Group, 75 Varick St, 9TH Flr, New York, NY 10013-1917, USA. (Nature Publishing Group - www.nature.com/; Nature Biotechnology - www.nature.com/nbt/)

Our news correspondents report that additional information may be obtained by contacting N.C. Kleinstreuer, Div DiscoveRx Inc, BioSeek, San Francisco, CA, United States. Additional authors for this research include J. Yang, E.L. Berg, T.B. Knudsen, A.M. Richard, M.T. Martin, D.M. Reif, R.S. Judson, M. Polokoff, D.J. Dix, R.J. Kavlock and K.A. Houck (see also Technology).

Keywords for this news article include: Chemicals, Chemistry, California, Technology, San Francisco, United States, North and Central America

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Biotech Week


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