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New Bioscience Study Results from Chinese Academy of Medical Sciences Described (Profiling of microRNAs under wound treatment in Aquilaria sinensis...

July 15, 2014



New Bioscience Study Results from Chinese Academy of Medical Sciences Described (Profiling of microRNAs under wound treatment in Aquilaria sinensis to identify possible microRNAs involved in agarwood formation)

By a News Reporter-Staff News Editor at Life Science Weekly -- A new study on Life Science Research is now available. According to news reporting out of Beijing, People's Republic of China, by NewsRx editors, research stated, "Agarwood, a kind of highly valued non-timber product across Asia, is formed only when its resource trees--the endangered genus Aquilaria are wounded or infected by some microbes. To promote the efficiency of agarwood production and protect the wild resource of Aquilaria species, we urgently need to reveal the regulation mechanism of agarwood formation."

Our news journalists obtained a quote from the research from the Chinese Academy of Medical Sciences, "MicroRNAs (miRNAs) are a group of gene expression regulators with overwhelming effects on a large spectrum of biological processes. However, their roles in agarwood formation remain unknown. This work aimed at identifying possible miRNAs involved in the wound induced agarwood formation. In this study, the high-throughput sequencing was adopted to identify miRNAs and monitor their expression under wound treatment in the stems of A. sinensis. The miR171, miR390, miR394, miR2111, and miR3954 families remained at the reduced level two days after the treatment. 131 homologous miRNAs in the 0.5 h library showed over three-fold variation of read number compared with the control library, of which 12 exhibiting strong expression alterations were further confirmed by real-time quantitative PCR. Target prediction and annotation of the miRNAs demonstrated that the binding, metabolic process, catalytic activity, and cellular process are the most common functions of the predicted targets of these newly identified miRNAs in A.sinensis."

According to the news editors, the research concluded: "The cleaveage sites of three newly predicted targets were verified by 5'RACE."

For more information on this research see: Profiling of microRNAs under wound treatment in Aquilaria sinensis to identify possible microRNAs involved in agarwood formation. International Journal of Biological Sciences, 2014;10(5):500-10 (see also Life Science Research).

Our news journalists report that additional information may be obtained by contacting Z.H. Gao, 1 Institute of Medicinal Plant Development, Chinese Academy of Medical Science & Peking Union Medicinal College (National Engineering Laboratory for Breeding of Endangered Medicinal Materials), Beijing 100193, People's Republic of China. Additional authors for this research include Y. Yang, Z. Zhang, W.T. Zhao, H. Meng, Y. Jin, J.Q. Huang, Y.H. Xu, L.Z. Zhao, J. Liu and J.H Wei.

Keywords for this news article include: Asia, Beijing, Life Science Research, People's Republic of China.

Our reports deliver fact-based news of research and discoveries from around the world. Copyright 2014, NewsRx LLC


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Source: Life Science Weekly


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